Pharmaceutical industry news

Reply to: Olaparib in Metastatic Breast Cancer: The Impact of Prior Cyclin-Dependent Kinase 4 and 6 Inhibitor Exposure on Efficacy

Intismeran Autogene Plus Pembrolizumab Versus Pembrolizumab Alone in High-Risk Resected Melanoma: 5-Year Update of the Randomized Phase IIb KEYNOTE-942 Study

He Was Always There

Olaparib in Metastatic Breast Cancer: The Impact of Prior Cyclin-Dependent Kinase 4 and 6 Inhibitor Exposure on Efficacy

COMBI-I: Long-Term Overall Survival With Spartalizumab Plus Dabrafenib and Trametinib in <i>BRAF</i> V600–Mutant Advanced Melanoma

Role of Risk-Reducing Bilateral Mastectomy in <i>BRCA1</i> and <i>BRCA2</i> Pathogenic Variant Carriers

Developing a Histology-Based Artificial Intelligence Biomarker to Predict Adjuvant Chemotherapy Benefit in Pancreatic Cancer

Should Artificial Intelligence Direct Systemic Therapy Decisions in Pancreatic Cancer?

Sustaining High Reliability Amid Artificial Intelligence Adoption in Oncology

Oncology Drug Development: Challenges of Increasingly Available Therapies

Impact of Tumor Genomic Profile on Adjuvant Chemotherapy Efficacy in Resected Pancreatic Adenocarcinoma: Results From the PRODIGE-24/CCTG PA6 Study

Development and Validation of a Computational Histology Artificial Intelligence–Powered Predictive Biomarker for Selection of Chemotherapy in Advanced Pancreatic Cancer

Phase II Clinical Study of Adebrelimab and Bevacizumab Combined With Cisplatin/Carboplatin in Patients With Triple-Negative Breast Cancer With Brain Metastases (ABC Study)

Magrolimab Plus Azacitidine Versus Placebo Plus Azacitidine in Patients With Untreated Higher-Risk Myelodysplastic Syndromes: The Phase III ENHANCE Study

Spotlighting rising researcher Lucas Attia: from drug nanoparticle engineering to molecular property prediction

Comparative changes in cardiovascular measures following speed, agility, and quickness training and small-sided games in youth football players: a randomized trial

Performance of artificial intelligence chatbots in restorative dentistry: a comparative analysis of clinical and theoretical specialty examination questions

Sterile neutrophilic pseudomembranous conjunctivitis associated with tisotumab vedotin: clinical and cytological evidence from two cases

Comparison of two tooth whitening treatments: a randomized split-mouth clinical trial

Clinical Observation on Four-Finger Pushing Manipulation Combined With Acupuncture in the Treatment of Cervical Vertigo

Clinical significance of inter-assay discrepancies and regression-derived correction of serum CA19-9 values: a comparison between CLIA and ECLIA

A Clinical Prediction Model for Self-Harm After Adolescent Traumatic Brain Injury

Vancomycin rescues sensitivity to isoniazid in clinical isolates of drug-resistant <i>Mycobacterium tuberculosis</i>

When tests don’t fit the rules: regulatory challenges for agnostic metagenomic next-generation sequencing in infectious diseases diagnostics

Indications, Techniques and Complications Associated With Pterygoid Implants: A Systematic Review and Meta‐Analysis

Diagnostic Yield of Brain MRI in Pediatric Short Stature: Hypothalamic–Pituitary Lesions and Incidental Findings in Real‐World Practice

The development and initial validation of the Perinatal Intrusions Interpretation Index: A novel scale that measures negative appraisals of infant‐related intrusive thoughts

The influence of social media on users’ intention to participate in clinical trials: a cross-country analysis using an adapted technology acceptance model

Price gouging in the B2B pharmaceutical market: a systematic review of unethical pricing, market manipulation, and regulatory challenges

Hypnosis for Postoperative Pain Management Following Colectomies: A Single-Center Randomized Controlled Feasibility Trial

Heart failure among people with HIV: prescription of guideline-directed medical therapy

A user-centric patient educational intervention in clinical practice: helping women to learn and share experiences about menopause

Autophagy activation in granulosa cells as a mechanism of astaxanthin action: evidence from a pilot randomised trial in PMOS-associated infertility

Silk sericin/fibroin composite drug delivery systems for lung cancer: mechanistic Rationale, potential functional complementarity, and future perspectives

Effects of Guided Imagery–Supported Psychoeducation on Self-Esteem, Perceived Stress, and Depressive Symptoms in Patients with Depression: A Randomized Controlled Trial

Applying Natural Language Processing to Address Healthcare Bias: Using CARE-SD to Evaluate the Distribution of Stigmatizing Language in Clinical Notes

When Fear Became the Barrier to Care — Lessons of a Clinical Rapid Response during Operation Metro Surge

A Virtual Reality Cardiopulmonary Bypass Simulator Versus Conventional Halstedian Observation for Early Perfusion Education: A Randomised Controlled Trial

How lipid ingestion is sensed: the mechanisms underlying intestinal hormone secretion

Differential detection of tau aggregation species using a small molecule probe for cell-based drug screening

Pre-treatment prediction of EBV-DNA status in nasopharyngeal carcinoma using CE-T1WI radiomics combined with clinical features: a multi-sequence MRI radiomics study

Integrating artificial intelligence and quantum chemistry for sustainable pharmaceutical retrosynthesis

Author Correction: Colonoscopy and fecal immunochemical testing versus usual care in diagnostic colorectal cancer screening: the SCREESCO randomized controlled trial

Aptamer-Functionalized DNA Frameworks as Targeted Drug Buffers for Concentration Regulation of Maytansine

An explainable AI framework for early mental health screening and clinical decision support using reflective listening and generative AI

Trust and the reliability of AI algorithms for clinical decision-making support in medicine: the MIRACLE case study

Potenzial und Herausforderungen von Large Language Models in der klinischen Entscheidungsfindung

The deubiquitinating enzyme regulatory network in malignant progression of breast cancer encompasses mechanisms of action, clinical significance and emerging therapeutic targets

Clinical, Laboratory and Radiological Factors associated with posterior reversible encephalopathy syndrome (PRES) in patients with eclampsia or pre-eclampsia: a systematic review and meta-analysis

Agreement between artificial intelligence and periodontists in the detection of periodontal bone loss on panoramic radiographs

Preserving beta cell function in children and adolescents with newly diagnosed stage 3 type 1 diabetes: per-protocol population analysis from the PROTECT randomised trial

NCT07813208: Ph+ ALL in Chinese Children: Diagnosis, Treatment, and Survival

Study type: OBSERVATIONAL. Phase: .

NCT07812636: Tirzepatide and Levonorgestrel IUD Therapy for EIN and Early-Stage Endometrial Cancer

Study type: INTERVENTIONAL. Phase: EARLY_PHASE1.

NCT07812402: The Effect of Factors Affecting Bone Mineral Density Measurement Results on Osteoporosis Diagnosis and Treatment Decision

Study type: OBSERVATIONAL. Phase: .

NCT07812142: Retrospective Analysis of the Second Year of Safety Surveillance of the Qdenga® (TAK-003) Vaccine in Private Vaccination Centers, Including a Sub-analysis of Safety in Adults Over 60 Years of Age

Study type: OBSERVATIONAL. Phase: .

NCT07811817: The Outcomes of Sympathetic Cardiac Denervation on Postoperative Atrial Fibrillation After Cardiac Surgery, Randomized Controlled Trial

Study type: INTERVENTIONAL. Phase: NA.

NCT07807579: Impact of Dexmedetomidine Versus Propofol on Intracranial Pressure in Adult Traumatic Brain Injury Patients: Randomized Controlled Double-Blind Trial

Study type: INTERVENTIONAL. Phase: PHASE4.

NCT07802639: Treatment for "Asymmetric Crying Facies"

Study type: INTERVENTIONAL. Phase: NA.

NCT07796880: Neoadjuvant Culmerciclib Combined With Endocrine Therapy for Hormone Receptor-Positive， Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07757334: Trauma-Focused Group Therapy for Adults With Trauma-Related Symptoms in Primary Care

Study type: INTERVENTIONAL. Phase: NA.