Pharmaceutical industry news

Serum sclerostin in relation to insulin resistance and epicardial fat thickness in obese women

Midwife-led birth place planning discussions outside of clinical guidance: a service evaluation

A Review of Osteosarcoma-Derived Exosomes in Tumor Progression, Chemoresistance, and Bone Regeneration, and Their Potential in Drug Delivery

Applications of Nanomaterials in Targeted Drug Delivery: An Initiation Toward the Development of Advanced Immunobiosensors

Clinical validation of Node-RADS for nodal staging in colon cancer: a retrospective study of 360 patients

Emergence of natalizumab anti-drug antibodies during extended interval dosing in a patient with multiple sclerosis: A case report

Corrigendum to SLAMF7 regulates the inflammatory response in macrophages during polymicrobial sepsis

Cell state programs offer a potential axis for classifying neuroendocrine tumors

A rare TMEM175 mutation drives Parkinson’s disease pathology by disrupting proton gating and lysosomal acidification

Supplementary Table S1 from Dual Inhibition of LAG-3 and PD-1 with IBI110 and Sintilimab in Advanced Alveolar Soft Part Sarcoma: A Single-Center, Phase II Trial

Supplementary Table S2 from Dual Inhibition of LAG-3 and PD-1 with IBI110 and Sintilimab in Advanced Alveolar Soft Part Sarcoma: A Single-Center, Phase II Trial

Supplementary Table S3 from Dual Inhibition of LAG-3 and PD-1 with IBI110 and Sintilimab in Advanced Alveolar Soft Part Sarcoma: A Single-Center, Phase II Trial

Supplementary Table S6 from Dual Inhibition of LAG-3 and PD-1 with IBI110 and Sintilimab in Advanced Alveolar Soft Part Sarcoma: A Single-Center, Phase II Trial

Supplementary Figure S1 from Multikinase Inhibition with Tinengotinib in Advanced Solid Tumors: Results from a Multicenter Phase Ib/II Trial

Supplementary Table S2 from Multikinase Inhibition with Tinengotinib in Advanced Solid Tumors: Results from a Multicenter Phase Ib/II Trial

Supplementary Table S8 from Multikinase Inhibition with Tinengotinib in Advanced Solid Tumors: Results from a Multicenter Phase Ib/II Trial

Supplementary Table S3 from Neoadjuvant Nivolumab plus Carboplatin and Paclitaxel in Patients with Locally Advanced Resectable Squamous Cell Carcinoma of the Head and Neck: A Phase II, Single-Arm Trial

Supplementary Table S5 from Neoadjuvant Nivolumab plus Carboplatin and Paclitaxel in Patients with Locally Advanced Resectable Squamous Cell Carcinoma of the Head and Neck: A Phase II, Single-Arm Trial

Supplementary Table S6 from Neoadjuvant Nivolumab plus Carboplatin and Paclitaxel in Patients with Locally Advanced Resectable Squamous Cell Carcinoma of the Head and Neck: A Phase II, Single-Arm Trial

Supplementary Table S4 from A Phase II Trial of Pembrolizumab plus Granulocyte–Macrophage Colony-Stimulating Factor in Advanced Biliary Cancer

Data from Impact of β-Blockers, Statins, and Cholinergic Agents on Clinical Outcomes in Pancreatic Cancer: A Retrospective VA Cohort Study

Supplemental Table 2 from Impact of β-Blockers, Statins, and Cholinergic Agents on Clinical Outcomes in Pancreatic Cancer: A Retrospective VA Cohort Study

AI-assisted nerve tracking for novices: a negative trial or an unanswered question?

Antipsychotic Doses in Patients With Tardive Dyskinesia Who Received Valbenazine

How Much Do Horizontally Referenced and Interteardrop-referenced Acetabular Coverage Indices Differ During Standing in Adults With Hip Pain?

Efficacy of a Validated Yoga-Breath Linked Intervention (Y-BLISS) for smoking cessation: A Randomized Controlled Trial

Hypocalcaemia and hospitalisation after initiation of bone-modifying agents in dialysis patients

Development and internal validation of survival models for predicting a composite clinical endpoint using clinical variables and quantitative SPECT/CT imaging features

Rupture of a right gastric artery pseudoaneurysm presenting with hemorrhagic shock two months after gastric endoscopic submucosal dissection

Clinical, dosimetric, and dietary factors associated with late radiation cystitis after prostate cancer radiotherapy

Transcriptomic profiling of severe acute pancreatitis reveals neutrophil-driven inflammatory signatures and a five-gene diagnostic panel

Reply to the letter to the editor from Drs. Delrue and Speeckaert regarding “inflammatory and traditional risk factors associated with the progression of chronic kidney disease in patients with rheumatoid arthritis”

P-Wave indices in the presence of atrial myxomas: a retrospective cohort analysis

Acupuncture for relief of gagging in patients undergoing transoesophageal echocardiography—a randomised placebo-controlled trial

NCT07910630: A Phase II Study Evaluating the Efficacy and Safety of Recombinant Human Truncated Plasmin Injection (JZB32) in Patients With Vitreomacular Traction

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07910058: An Investigator-initiated, Prospective, Open-label, Multicenter Randomized Controlled Trial, Comparing the Efficacy of Sacubitril/Valsartan and Standard Treatment on Atrial Fibrillation Recurrence After Catheter Ablation in Persistent Atrial Fibrillation Patients Without Hypertensive

Study type: INTERVENTIONAL. Phase: PHASE4.

NCT07909928: Biologic Augmentation of Osteochondral Allograft Transplantation in the Knee

Study type: INTERVENTIONAL. Phase: NA.

NCT07909538: The Effectiveness of Structured Swallowing Exercise Therapy in Patients With Nasopharyngeal Carcinoma: An Assessment of Swallowing Function and Quality of Life

Study type: INTERVENTIONAL. Phase: NA.

NCT07909434: A Study of Mesothelin-Targeted CAR-Mix Cells in Patients With Advanced Solid Tumors

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07909239: LBBAP Versus ILR in Patients With New-Onset LBBB and Moderately Reduced LVEF After TAVI

Study type: INTERVENTIONAL. Phase: NA.

NCT07909005: Long Term Safety Study in Patients With HLH/MAS in Still's Disease Exposed to Gamifant.

Study type: OBSERVATIONAL. Phase: .

NCT07908888: Efficacy and Safety of Polatuzumab Vedotin, Rituximab Combined With Reduced-dose Cyclophosphamide, Doxorubicin and Prednisone Regimen in the Treatment of Elderly Patients With Diffuse Large B-cell Lymphoma: A Multicenter, Single-arm, Prospective Study

Study type: INTERVENTIONAL. Phase: PHASE4.

NCT07908576: Cholecystectomy, Biliary Diseases, and Colorectal Adenoma Risk: A Real-World Retrospective Study

Study type: OBSERVATIONAL. Phase: .

NCT07905131: A Study of Perioperative Navlimetostat Combined With Modified FOLFIRINOX in Patients With MTAP-Deleted Pancreatic Cancer

Study type: INTERVENTIONAL. Phase: PHASE1, PHASE2.

NCT07903727: Results of Medical and Nursing Record,PE, Blood Test and Radiological Examination ,Morality and Mobility of Multiple Trauma of Patient's

Study type: OBSERVATIONAL. Phase: .

NCT07891728: A Multicenter Evaluation of SalivIQ™ Strep A for Detecting Group A Streptococcus From Saliva and Throat Swabs in Patients With Acute Pharyngitis

Study type: OBSERVATIONAL. Phase: .

NCT07891468: huCART19-IL18-CD428z Cells for the Treatment of Patients With HIV With CD19+ Cancers

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07888322: Assessment of Intelligent Algorithms for Detection, Diagnosis and Risk Stratification of Tumors of the Kidney and Prostate

Study type: OBSERVATIONAL. Phase: .

NCT07832630: Saruparib in HRDsig+ Solid Tumors

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07796373: Nemtabrutinib for Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Leukemia (SLL) Refractory to Covalent Bruton Tyrosine Kinase Inhibitor or Pirtobrutinib and Previously Treated With a BCL2 Inhibitor

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07777211: A Study of GKL-006 Injection in Patients With Advanced Pancreatic Cancer

Study type: INTERVENTIONAL. Phase: PHASE1, PHASE2.

NCT07775807: Closed-loop TBS Targeting rPO for the Core Clinical Features of Methamphetamine Use Disorder

Study type: INTERVENTIONAL. Phase: NA.

NCT07756684: Feasibility of Cough Skill Training in Individuals With Head and Neck Cancer

Study type: INTERVENTIONAL. Phase: NA.

NCT07756580: A Study to Evaluate Sequential Administration of Injections of AGN-151586 Followed by BOTOX in Adult Participants for Treatment of Glabellar Lines

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07732101: Exercise Intervention for Breast Cancer Patients With Sarcopenia

Study type: INTERVENTIONAL. Phase: NA.

NCT07720531: Generative AI-Powered Intrapartum Clinical Decision Support Among Healthcare Providers

Study type: INTERVENTIONAL. Phase: NA.

NCT07687485: Tricuspid Regurgitation Treatment With LAPLACE Transcatheter Tricuspid Valve Replacement System

Study type: INTERVENTIONAL. Phase: NA.

NCT07672483: IL-12 Genetically Engineered Myeloid Cells in Participants With Relapsed, Refractory Solid Tumors

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07647029: A Clinical Study on Prophylactic RespOnse To hEtrombopag for Secondary Prevention in Anti-Cancer Therapy-induced Thrombocytopeniae

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07619365: Trastuzumab Deruxtecan and Lovastatin in HER2-low and Ultralow Advanced or Metastatic Breast Cancer

Study type: INTERVENTIONAL. Phase: PHASE2.