Pharmaceutical industry news

High Concordance in Molecular Profiles Between Primary Tumors and Matched Lymph Node Metastases in Differentiated Thyroid Carcinoma: Implications for Clinical Sample Selection

Immune-related liver injury: Clinical and histological subtyping defines distinct trajectories and therapeutic implications

Clinical Outcomes of 6-Fr vs 8-Fr Catheters in Percutaneous Transhepatic Gallbladder Drainage: A Propensity Score-Matched Analysis

Integrating Creative and Community Health Services into Clinical Workstreams: A Qualitative Case Study from Gloucestershire Integrated Care Board

Genomic characterization of the first near-complete goat-associated Orf virus genome sequenced directly from a human clinical sample in Portugal

Predictors of achieving remission in rheumatoid arthritis during levilimab therapy in real-world clinical practice

Lupus nephritis in patients from Kyrgyzstan: clinical and laboratory manifestations, disease course variants, and prognostic factors for development

Prospective evaluation of the effect of stopping estrogen-containing contraceptives on serum CBG and cortisol levels

Does Metabolically Healthy Obesity Really Exist: Going Toward New Definitions

Deciphering the role of adipose tissue microbial DNA in obesity-related metabolic dysfunction

Speech-evoked auditory brainstem response as a biomarker of auditory plasticity: clinical and neurophysiological perspectives — a narrative review

How glycemic variability trajectories impact clinical outcomes in critically ill patients with severe pneumonia: a prospective cohort study

A systematic review on clinical and laboratory effects of vitamin D deficiency in children with sickle cell disease

A Pragmatic SMART Study of Medication and CBT Sequencing in Pediatric Anxiety Disorders: A Randomized Clinical Trial

Update in Diagnosis and Management of Glucocorticoid-Induced Osteoporosis

Roles and Responsibilities of Nutrition Nurses

Periprocedural Cooling During Botulinum Toxin Injection: Surface Temperature Effects and Practical Clinical Considerations

A Conversation With ... Malcolm Willett, Cartoonist Who Looks at Us With a Wry Smile

Real-world recurrence-free and distant metastasis-free survival in early-stage melanoma: concordance with KEYNOTE-716 trial estimates

Closing the Gap Between Trial and Clinical Reality in Long-term LVAD Use Outcomes

A Multi-Centre Real-World Evaluation of Ritlecitinib in Severe Alopecia Areata: Early Real World Experience in a British Cohort

A Review of Male Genital Psoriasis

A novel drug screening strategy based on non-invasive electrochemical detection of multiple tumor markers secreted by patient-derived microgel organoids

Neurobiomarker-guided neuromodulation for youth with major depressive episodes: a double-blind randomized trial

From breadth to depth in clinical artificial intelligence evaluation

Retraction Note: Carbon nano-onion-mediated dual targeting of P-selectin and P-glycoprotein to overcome cancer drug resistance

Efficacy and safety of hydrolyzed collagen supplementation on skin health outcomes: a systematic literature review of randomized controlled trials

Aprepitant’s neuroprotective effects on methylphenidate-induced biochemical/mitochondrial dysfunction, neuroinflammation, and mood-related behavior alterations

Mechanistic Insights into LGALS3-Mediated Osteoarthritis Progression: Activation of the cGAS-STING Pathway as a Key Driver of Senescence-Related Osteoarthritis

Multiparametric Characterization of Tough Clots Following Stroke Thrombectomy

“Protected time” for clinical investigators in medical oncology: The persistent gap between expectation and reality

NCT07666477: rTMS and Olfactory Training for Parkinson's Disease

Study type: INTERVENTIONAL. Phase: NA.

NCT07665762: Liposomal Bupivacaine Plus Plain Bupivacaine Versus Dexamethasone Plus Plain Bupivacaine in the Supraclavicular Brachial Plexus Block in Patients With Risk Factors for Severe Acute Postoperative Pain

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07665268: Study Title: A Multicenter, Prospective, Modified Platform Trial Evaluating Several Cellular, Acellular, and Matrix-like Products (CAMPs) and Standard of Care Versus Matched Standard of Care Controls in the Management of Nonhealing Pressure Ulcers.

Study type: INTERVENTIONAL. Phase: PHASE4.

NCT07664644: Hybrid Type 1 Trial of a Parent-Based Intervention Addressing Social Media and Adolescent Alcohol Use

Study type: INTERVENTIONAL. Phase: NA.

NCT07659197: Usefulness of the VExUS Protocol for Dry-Weight Adjustment in Hemodialysis Patients: The Multicenter VExHD Study

Study type: INTERVENTIONAL. Phase: NA.

NCT07553715: Effectiveness of a Four-Session Focal Shock Wave Therapy Protocol in Women With Vulvodynia

Study type: OBSERVATIONAL. Phase: .

NCT07496697: Effects of Electroacupuncture at NP82 and SP15 on Bowel Motility in Healthy Subjects

Study type: INTERVENTIONAL. Phase: NA.

NCT07419490: Utero-ovarian Transposition in Patients With Pelvic Malignancies Undergoing Whole Pelvic Radiotherapy

Study type: INTERVENTIONAL. Phase: NA.

NCT07407920: Ph2 Study for Optimization of Adjunct Systemic Therapy in HER2+ Patients, MolecularPCR Trial

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07376486: Duodenal pulsENDO as an Early Treatment for Type 2 DM

Study type: INTERVENTIONAL. Phase: NA.

NCT07206589: Minimally Invasive Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Cancer, SOS5C Trial

Study type: INTERVENTIONAL. Phase: NA.

NCT07193550: A Phase 2 Trial of Zanzalintinib in Advanced/Metastatic Bone Sarcomas (ZAMBONE)

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07009171: Study to Evaluate the Efficacy and Safety of KDS2010 in Overweight or Obese Patients

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT06952010: A Study of XB628 Alone and in Combination With Zanzalintinib in Participants With Recurrent Advanced or Metastatic Solid Tumors

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT06892548: A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer

Study type: INTERVENTIONAL. Phase: PHASE1, PHASE2.

NCT06673628: Pembrolizumab Plus Lenvatinib in Unresectable Cutaneous Angiosarcoma Patients

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT06661122: A Study to Learn About How Safe Darolutamide is and How Well it Works in Combination With Androgen Deprivation Therapy and Docetaxel in Routine Medical Care for Japanese Men With Low Volume Metastatic Hormone-Sensitive Prostate Cancer

Study type: OBSERVATIONAL. Phase: .

NCT06595953: Gaze-Contingent Music Therapy Augmentation of CBT for Pediatric Anxiety

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT06238622: A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT05831085: Diabetes-Centered Evaluation of Revascularization Strategy of Functional and Imaging-CombiNEd State-of-the-Art Percutaneous Coronary Intervention or Coronary-Artery Bypass Grafting in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease

Study type: INTERVENTIONAL. Phase: NA.

NCT05519553: Peer Support Impact on Therapeutic Adherence in Patients With Multiple Sclerosis

Study type: INTERVENTIONAL. Phase: NA.

NCT05280548: A Study to Evaluate the Effect of Venglustat Tablets on Left Ventricular Mass Index in Male and Female Adult Participants With Fabry Disease

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT04570423: A Study to Evaluate the Safety and Pharmacokinetics of Eflapegrastim in Pediatric Participants With Solid Tumors or Lymphomas and Treated With Myelosuppressive Chemotherapy

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT04323540: Treatment of Peri-implantitis With or Without Simultaneous Soft Tissue Augmentation

Study type: INTERVENTIONAL. Phase: NA.

NCT04067219: SkIn, Muscle and Bone Aging Determinants in HIV Infected-patients.

Study type: INTERVENTIONAL. Phase: NA.

NCT02858323: Complement (C1q) Binding to HLA Antibodies in a Solid-phase Immunoassay and Clinical Effect on Platelet Transfusion

Study type: OBSERVATIONAL. Phase: .

NCT01989572: Sargramostim, Vaccine Therapy, or Sargramostim and Vaccine Therapy in Preventing Disease Recurrence in Patients With Melanoma That Has Been Removed By Surgery

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT01575548: Pazopanib Hydrochloride in Treating Patients With Metastatic Kidney Cancer Who Have No Evidence of Disease After Surgery

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT01352949: Stereophotogrammetry of the Torso in Healthy Individuals and Patients With Scoliosis, Chest Wall Deformations, or Obesity

Study type: OBSERVATIONAL. Phase: .