Pharmaceutical industry news

Data-Driven Clinical Phenotyping of Adult Epilepsy Using Latent Class Analysis: A Regional Cohort Study from Southern Kazakhstan

Artificial Intelligence-Assisted Detection of the Elongated Styloid Process on Dental Radiographic Images: A Systematic Review and Literature Update

Trastuzumab Emtansine–Associated Porto-Sinusoidal Vascular Disorder: Clinical Features and Outcomes from Published Cases

Not All Microbiomes Reflect Chronic Pain: Evidence from the Urinary Tract in a Case–Control Study

Dynamic Voice Optimization After Type I Thyroplasty Using a Novel Adjustable Implant: A Prospective Longitudinal Study

Professional Roles and Work-Related Challenges of Anti-Drug Social Workers in Community-Based Drug Rehabilitation: A Systematic Review

Integrating Physiatry and Palliative Care in Outpatient Oncology: A Clinical Framework for Bidirectional Referral and Co-Management

Sedentarism Exhibits a Distinct Mitochondrial Bioenergetic Phenotype Detectable by Cardiopulmonary Exercise and Lactate Testing (CPELT)

Trial of FastEddy Simulation of Building-Induced Airflow and the Comparison with LIDAR and Flight Data in an Operating Airport

K-anonymity decay in multi-turn clinical large language model conversations

Chronic Viral Hepatitis with Concurrent MASLD: Dual Etiology Challenges

Clinical utility of liquid biopsy in biliary tract cancer: Diagnosis to treatment monitoring

Correção de apinhamento dentário, associado a desvio de linha média, por meio de alinhadores impressos em 3D com memória de forma sem uso de attachments: Relato de caso clínico

Peer Review Report For: Viral hepatitis and liver disease in the Mongolian community in London ('MoLo'): A mixed methods study protocol to investigate the epidemiology and burden of disease to inform clinical and public health interventions [version 1; peer review: 2 approved]

Prediction Model for Severe Complications in Patients with Failed Conservative Treatment of Acute Intestinal Obstruction Based on Clinical and Imaging Features: Development and Validation

Clinical Pharmacology of Heart Failure in Frailty

Pharmaceutical import landscape in Ethiopia: a cross-sectional study of importers’ perspectives on business and regulatory challenges

Pre-emptive treatment in later-onset urea cycle disorders: a clinical perspective on glycerol phenylbutyrate

Fibroblast activity biomarkers are associated with mortality in severe COVID-19: a post-hoc analysis of a phase 2 clinical trial

Efficacy of codesigned COVID-19 booster vaccine promotion materials for long-term care staff: a cluster-randomized trial

Associations of anthropometric-related phenotypes with functional and clinical outcomes in community-dwelling older adults: a cross-sectional analysis of ELSI-Brazil

Microbial profile and antimicrobial resistance patterns in clinical specimens from a secondary-level hospital in Accra, Ghana: a five-year retrospective study

Determinants of out-of-home activity in older adults with cognitive impairment following inpatient rehabilitation: A secondary cross-sectional analysis of a randomised controlled trial using location-based and accelerometer-derived measures

Redefining Radiotherapy: The Gut as an Active Target in Immuno-oncology

Medical student experience with an 8-week online mindfulness training program: Qualitative findings from a mixed-method randomised controlled trial

Effectiveness of a chronic care model-based transitional care program for patients with biliary drainage: a randomized controlled trial

Less Is More! An Analysis of Postoperative Outcomes Comparing Low-Dose E. Coli-Derived rhBMP-2 and Mammalian rhBMP-2 in Lateral Lumbar Spinal Fusion Surgery

Start, Stop & Select: The Steward's Hat Trick

Advancing beyond stand-alone NAb assays: perspectives and regulatory impact of applying integrated immunogenicity assessment in drug development

Navigating PD-L1 testing in immuno-oncology: analytical robustness, clinical validation, and the role of the VENTANA SP263 assay

Interrelating strategy and architecture moves: a clinical inquiry into a strategic digital initiative

Comparison of Radiation Exposure on the Control Panel Side Versus the Opposite Side During C-Arm Fluoroscopy-Guided Blocks: Randomized Controlled Trial

A nationwide histopathology study reflecting the impact of the introduction of MRI in the diagnostic trajectory of prostate cancer in routine clinical care

Management of venous thromboembolism in France – a nationwide clinical practice survey among vascular medicine specialists

Associations of length of stay with sarcopenia parameters in geriatric patients: age and sex differences in the oldest old

Tumor organoid platform design for drug response modeling: culture architecture, microenvironmental complexity, and AI-assisted readouts

Cone-Beam Computed Tomography-Based Oropharyngeal Airway Narrowing Assessment: A Systematic Review of Methodologies, Measurements, and Clinical Associations

Out-of-field and in-field teachers’ professional learning gains on fostering understanding of multiplication: A randomized controlled trial

Surgical strategies and long-term survival for third ventricle chordoid gliomas: a systematic review and clinical algorithm

Effectiveness of low-level laser therapy compared to standard postoperative care on pain intensity and cesarean section wound healing in the immediate postoperative period: a randomized clinical trial

Unraveling clade-specific differences in Candida auris: evolution, adaptation, and pathogenicity

Adjunctive postoperative vitamin B complex with ibuprofen for pain and soft-tissue healing after impacted mandibular third molar surgery: a split-mouth randomized clinical trial

Iridology: Biological plausibility, clinical evidence, and implications for ophthalmic practice

Unveiling dry eye disease prior to cataract surgery: A multicenter clinical study

Severe Pediatric Snakebite With Coagulopathy and Compartment Syndrome: Conservative Management With Plasma Exchange

Intentional replantation with apical periodontal ligament preservation: A case report

NCT07669792: Khoury's Bone Shell Technique Versus Titanium-Reinforced Polytetrafluoroethylene for Augmentation of Horizontal Deficiency in Posterior Mandible (Histomorphometry Analysis): A Randomized Clinical Trial

Study type: INTERVENTIONAL. Phase: NA.

NCT07669402: Comparative Evaluation of Letrozole, L-Carnitine, and Combination Therapy on Sperm Quality and ART Outcomes in Idiopathic Oligoasthenoteratozoospermia: A Three-Arm Randomized Trial

Study type: INTERVENTIONAL. Phase: PHASE2, PHASE3.

NCT07669324: Effect of Chemical and Light Bleaching Techniques on Color Change, Dentin Hypersensitivity and Patient Satisfaction

Study type: INTERVENTIONAL. Phase: NA.

NCT07668570: SBRT Plus QL1706 as Second-Line Therapy for Hepatocellular Carcinoma

Study type: INTERVENTIONAL. Phase: PHASE4.

NCT07668388: A Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 Diabetes

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07668375: Outcome of Treatment With Botulinum toxinA in Patients With Temporomandibular Myofascial Pain

Study type: INTERVENTIONAL. Phase: PHASE4.

NCT07667699: Multidimensional Determinants of Functional Health In Women Aged 45-60

Study type: OBSERVATIONAL. Phase: .

NCT07667361: Time to Healthy Lifestyle Habit Using Digital Health Tools in Adults at Risk of Diabetes

Study type: INTERVENTIONAL. Phase: NA.

NCT07488923: A First-in-human (FIH), Phase 1 Study of ML261, an Autologous Potency Enhanced Anti-DLL3 CAR T Cell Therapy, in Participants With R/R SCLC or Select NECs (SPECTRAL-1)

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07424157: Long-Term Follow-Up of Subjects Treated With Seattle Children's Therapeutics Gene Therapy Products

Study type: OBSERVATIONAL. Phase: .

NCT07223398: Shared Decision Making to Treat Or Prevent (STOP) HIV in Criminal Legal Involved Populations (R33)

Study type: INTERVENTIONAL. Phase: NA.

NCT07216482: A Clinical Study of Enlicitide in Participants With High Cholesterol (MK-0616-037)

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07003542: A Phase 2 and Pharmacodynamic Study of Sitagliptin in Patients With Progressive Grade 4 Gliomas

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT06963580: Efficacy of MI078 Capsules in Treating Postpartum Depression

Study type: INTERVENTIONAL. Phase: PHASE2.