Pharmaceutical industry news

The Role of Thyroid Disease and Other Biomarkers in Invasive Breast Cancer: A 3-year Retrospective Comparative Study

Clinical Data Review of the CATHTRONIX Intravascular PTA Balloon Dilatation Catheter: Clinical Safety, Clinical Performance and Clinical Benefit Evaluation with Hospital-Based Clinical Follow-Up and State-of-the-Art Literature Appraisal

Large Language Models for World Health Organization–Uppsala Monitoring Centre Drug–Adverse Event Causality Assessment Using Food and Drug Administration Adverse Event Reporting System Cases: Comparative Performance Study

An Evidence-Based Cognitive Stimulation and Physical Activity Intervention to Delay Aging-Related Decline: Protocol for a Randomized Controlled Trial

In Vivo Evaluations of Drug Delivery to the Brain

Exosomes for Drug Delivery to the Brain

Association between the ZJU Index and clinical outcomes in patients with acute myocardial infarction

Artificial intelligence in shoulder arthroplasty: latest concepts and clinical integration

Clinical rationale for thymic restoration in adult immunosenescence

Dental students’ perceptions of preclinical and clinical prosthodontic education: a cross-sectional survey

The effect of foraminal enlargement and irrigant activation technique on post-operative pain in necrotic teeth - a clinical study

Clinical characteristics and risk factors for mortality in pulmonary mucormycosis among patients with non-hematologic malignancies

Continuous adductor canal block versus continuous femoral nerve block for analgesia after open reduction and internal fixation of patellar fractures: a randomized controlled trial

Incidence and clinical characteristics of taxane-induced peripheral neuropathy requiring treatment in patients with breast cancer

Clinical Triage of Individuals With Warning Symptoms of Imminent Cardiac Arrest

Impact of vitamin D on the colon cancer immune microenvironment: results of a randomized clinical trial of preoperative vitamin D supplementation in patients with stage I-III colon cancer

Hepatitis B virus core immunoglobulin M: false positive more common than true

A sensitive and reduced-cost culture medium for recovery of <i>Clostridioides difficile</i> isolates with reduced fidaxomicin susceptibility from stool

AV Node Ablation and Conduction System Pacing Versus Biventricular Pacing in Patients With AF and HF

Right aortic arch and double arch: current clinical challenges

A point prevalence survey on antibiotic dispensing practices identifies targets for quality improvement of antimicrobial stewardship in community pharmacies in Dar es Salaam, Tanzania

Belantamab mafodotin, a BCMA-directed antibody-drug conjugate for multiple myeloma

Therapeutic use of cardioselective beta-blockers for patients with chronic obstructive pulmonary disease: a review of current clinical evidence

Multilevel brain heart interaction correlates with suicidal ideation in first episode drug naive major depressive disorder

Olaparib in HR-deficient, metastatic triple-negative breast and platinum-sensitive relapsed ovarian cancers without germline mutations in BRCA1/2: phase 2 EMBRACE trial

FDA approves novel cell therapy made with haematopoietic stem cells, Tregs and T cells

CAR T cell therapy for solid cancer scores first approval in China

Hydrogen- and Fluorine-Functionalized Germagraphene Quantum Dots: DFT Studies and Implications for Anticancer Drug Delivery

Killing the Messiah: The Trial and Crucifixion of Jesus of Nazareth By Nathaniel J. Andrade, Oxford: Oxford University Press, 2025. 273 pp.

The Costs of Partner Engagement in Research: Opportunities for Pragmatic Research, Implementation Science, and the Science of Engagement

Epidemiological landscape and clinical heterogeneity of primary pancreatic lymphoma: a population-based study

Exploring the mechanism by which triphenyl phosphate promotes malignant phenotypes in bladder and kidney cancer through MMP9 based on bioinformatics analysis and experimental validation

Low-dose, not low-risk: potential adrenal suppression identified by a risk-based approach to ACTH testing

Effects of exercise on physical function and pain in adults with rheumatoid arthritis: an exit meta-analysis of randomized controlled trials

Towards Multidisciplinary Summarization of Hospital Stays: Efficient Sentence-Level Clinical Section Categorization

Machine Learning for Early Prediction of Gestational Diabetes Mellitus Using Routinely Collected Clinical Data

Ontology-Aligned Clinical NER in Emergency Medicine Using Weak Supervision

Reasoning-Enhanced Rare-Event Prediction with Balanced Outcome Correction for Clinical Decision Support

Transforming Hospitals with Artificial Intelligence: Applications in Clinical Education and Patient Care

Bone stability after regenerative peri‐implantitis treatment: A 10‐year follow‐up case study

NCT07691255: MELanoma Brain Metastasis Treated With CYberknife

Study type: OBSERVATIONAL. Phase: .

NCT07691216: Retrospective Observational Multicenter Study on the Burden of Hospitalized Patients With Respiratory Tract Infection

Study type: OBSERVATIONAL. Phase: .

NCT07690774: AI-Assisted Versus Conventional Orthodontic Diagnosis and Treatment Planning

Study type: OBSERVATIONAL. Phase: .

NCT07689539: Trial of DN022150 Versus Chemotherapy in Previously Treated Advanced Pancreatic Cancer With KRAS G12D Mutation

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07689279: Selection of Transcatheter Heart vaLve With Intermediate Sizing in Patients With Severe Aortic Stenosis Treated With Transcatheter Aortic Valve Replacement

Study type: INTERVENTIONAL. Phase: PHASE4.

NCT07680114: Overnight Thalamic TES-TI to Modulate Sleep Spindles in Individuals With Schizophrenia Spectrum Disorders and Matched Healthy Controls

Study type: INTERVENTIONAL. Phase: NA.

NCT07675785: PfSPZ-LARC2 Vaccine in Women of Child-bearing Potential (WOCBP) in Mali

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07620951: Material Balance of [14C]Zorifertinib in Healthy Adult Male Participants in China

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07545837: Health and Wellness Coaching to Improve Adherence to Healthy Habits and Treatment Plans in Papillary and Follicular Thyroid Cancer Survivors

Study type: INTERVENTIONAL. Phase: NA.

NCT07443930: Musicians' Health Education in D-A-CH

Study type: OBSERVATIONAL. Phase: .

NCT07406620: Entropy-based Physiological Signal Analysis in Patients With Obstructive Sleep Apnoea

Study type: OBSERVATIONAL. Phase: .

NCT07355062: A Study to Evaluate the Efficacy and Safety of Veverimer for the Treatment of Metabolic Acidosis

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07339033: [Trial of device that is not approved or cleared by the U.S. FDA]

Study type: . Phase: .

NCT06933251: PCSK9 Inhibitor and PD-1 Inhibitor Combined With Neoadjuvant Chemoradiotherapy for pMMR/MSS Locally Advanced Rectal Cancer

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT06424769: Improving Outcomes and Reducing Disparities for Patients With Inflammatory Bowel Disease Through Epidemiology and Enhanced Disease Management

Study type: INTERVENTIONAL. Phase: NA.

NCT05221502: Safety and Efficacy Evaluation of 4-month Regimen of OPC-167832, Delamanid and Bedaquiline in Participants With Drug-Susceptible Pulmonary TB

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT05142592: Phase1/2a Study for IPG7236 in Patients With Advanced Solid Tumors

Study type: INTERVENTIONAL. Phase: PHASE1, PHASE2.

NCT05038735: Study to Assess the Efficacy and Safety of Alpelisib Plus Fulvestrant in Participants With HR-positive (HR+), HER2-negative, Advanced Breast Cancer After Treatment With a CDK4/6 Inhibitor and an Aromatase Inhibitor.

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT04567420: DNA-guided Second Line Adjuvant Therapy for High Residual Risk, Estrogen Receptor Positive, HER-2 Negative Breast Cancer (DARE)

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT04499534: BRCA1/2 Flu Vaccine

Study type: OBSERVATIONAL. Phase: .