Pharmaceutical industry news

From Daffodils to Drug Leads: Amaryllidaceae Alkaloids Target Protein Translation in Chronic Lymphocytic Leukemia to Induce Selective Apoptosis

Maladaptive movement in eating disorders: clinical correlates and cross-cultural adaptation of the Czech exercise and eating disorders questionnaire

Gut microecology and cardiovascular disease: core pathogenic mechanisms and clinical intervention strategies

Burnout Factors for Pediatric Psychologists Across Career Stages

Oligoclonal band count as a marker of MRI lesion burden and clinical profile in newly diagnosed multiple sclerosis

Clinical and MRI features associated with remission following biological therapy in axial spondyloarthritis

Repeated perioperative hypersensitivity reactions and positive challenge testing strongly suggest sevoflurane hypersensitivity: a clinical report with supportive basophil activation testing

Safety of Nonsteroidal Anti‐Inflammatory Drug Use in Traumatic Brain Injury

Pharmacokinetics of Loading Dose Vigabatrin Administered via Enteral Tube in Participants With Post‐Anoxic Status Epilepticus

Responsible Implementation of EHR-Based Clinical Prediction Models—Beyond Performance

NCT07816575: Comparative Efficacy of Alpha Hydroxy Acids With and Without Nanocarriers Versus Calcipotriol Plus Betamethasone in Treatment of Plaque Psoriasis

Study type: INTERVENTIONAL. Phase: NA.

NCT07816510: Combination of Oral Antifungal Treatment for Refractory Dermatophytosis

Study type: INTERVENTIONAL. Phase: NA.

NCT07816328: Investigation of a Remibrutinib- and Omalizumab-based Treatment Algorithm in Adult Patients With Chronic Spontaneous Urticaria Inadequately Controlled by H1-antihistamines Within 24 Weeks

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07815626: Phase 3 Study to Evaluate the Efficacy and Safety of Human Growth Hormone Injection (Sinotropin AQ) for the Treatment of Children With Idiopathic Short Stature

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07815301: Gradual Tapering or Discontinuation of Beta-Blockers After Stabilization With Mavacamten Therapy

Study type: INTERVENTIONAL. Phase: NA.

NCT07814365: PBI for Low-risk Breast Cancer

Study type: INTERVENTIONAL. Phase: NA.

NCT07813949: Evaluation of Clinical Performance, Shade Matching, and Patient Satisfaction of Different Resin Composite Layering Techniques Using 3D Printed Cast

Study type: INTERVENTIONAL. Phase: NA.

NCT07714538: Breath Research Narrow Validation for Gastrointestinal Cancer Detection

Study type: OBSERVATIONAL. Phase: .

NCT07597746: "Effects of a Combined Repetitive Transcranial Magnetic Stimulation and Physical Therapy Protocol on Motor Function, Balance, and Quality of Life in Chronic Post-Stroke Hemiplegia: A Case Series"

Study type: INTERVENTIONAL. Phase: NA.

NCT07597161: [Trial of device that is not approved or cleared by the U.S. FDA]

Study type: . Phase: .

NCT07593079: Prostate Specific Membrane Antigen (PSMA) Imaging for Detection of Residual and Metastatic Prostate Cancer

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07575685: Enhancing Cancer Care: RestoreMe App for Personalized Nutrition and Activity in Cancer Patients

Study type: INTERVENTIONAL. Phase: NA.

NCT07566156: Enfortumab Vedotin in Combination With Pembrolizumab vs. Concurrent Chemoradiotherapy (cCRT) in People With Muscle Invasive Bladder Cancer (EV-309)

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07557420: Efficacy, Safety, Pharmacokinetics, Pharmacodynamics, and Immunogenicity Study of Ravulizumab in Chinese Adults With Neuromyelitis Optica Spectrum Disorder (NMOSD)

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07489378: NCI Childhood Cancer Data Initiative (CCDI) Led Pediatric, Adolescent, and Young Adult Rare Cancer Registry for Very Rare Solid Tumors

Study type: OBSERVATIONAL. Phase: .

NCT07416786: Validation of NAD+ Measurements for Human Clinical Studies

Study type: INTERVENTIONAL. Phase: NA.

NCT07391774: Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07388537: Evaluation of the Clinical Spectrum of Diabetes and Obesity in Youth and Adults

Study type: OBSERVATIONAL. Phase: .

NCT07370974: Effect of Clinical Hypnosis in Preoperative Anxiety Among Patients Undergoing an Abdominal Surgery.

Study type: INTERVENTIONAL. Phase: NA.

NCT07278739: Testing an Educational Program to Improve Goals of Care Conversations Between Patients and Their Care Teams

Study type: INTERVENTIONAL. Phase: NA.

NCT07226349: A Study of BG-75098 Alone and in Combination With Other Agents in Adults With Advanced Solid Tumors

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07103109: Impact of Proximal Motor Control Exercise on Scapular Muscles Activation Pattern in Breast Cancer Survivors Following Mastectomy

Study type: INTERVENTIONAL. Phase: NA.

NCT07091149: Digital Cognitive Behavioral Treatment of Insomnia in Youth: An RCT Examining Feasibility, Acceptability, and Efficacy of NiteCAPP Jr

Study type: INTERVENTIONAL. Phase: NA.

NCT06921850: A Study to Assess the Pharmacokinetics and Safety of Bimekizumab in Children and Adolescents With Moderate to Severe Hidradenitis Suppurativa

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT06920511: Cognitive Rehabilitation With Virtual Reality in Parkinson Disease

Study type: INTERVENTIONAL. Phase: NA.

NCT06899633: Multicenter, Observational, Descriptive Study of the Diagnosis, Course and Treatment of Patients With SLE in Routine Practice in Kazakhstan: a Registry Study With Retrospective and Prospective Components.

Study type: OBSERVATIONAL. Phase: .

NCT06681662: Ephedrine for Reducing Onset Time of Rocurinium in Elderly Patients

Study type: INTERVENTIONAL. Phase: PHASE4.

NCT06562803: Efficacy and Safety of Cytokine Adsorption and Plasma Exchange in Patients With ACLF and Sepsis

Study type: INTERVENTIONAL. Phase: NA.

NCT06429761: Phase 4 Study to Assess the Safety of Trastuzumab Deruxtecan, in Indian Patients

Study type: INTERVENTIONAL. Phase: PHASE4.

NCT06292845: Ex Vivo Tumor Visualization and Resection Margin Assessment Using Topically Applied Fluorescent Imaging Agents

Study type: INTERVENTIONAL. Phase: NA.

NCT06200246: Cardio-vascular Energy Transfer and Ventriculo-arterial Coupling in Heart Failure

Study type: OBSERVATIONAL. Phase: .

NCT06200155: Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT05985954: Open-label Phase 1b Study of Ulixertinib and Cetuximab or Ulixertinib in Combination With Cetuximab and Encorafenib in Patients With Unresectable or Metastatic Colorectal Cancer Who Have Previously Received EGFR or BRAF-directed Therapy

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT05924464: Group Preconception Care for Fertility Patients

Study type: INTERVENTIONAL. Phase: NA.

NCT05920356: A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT05885555: A Study of Ianalumab (VAY736) in Patients With Primary Immune Thrombocytopenia (ITP) Previously Treated With at Least Two Lines of Therapies

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT05630794: Testing for Safety and Colorectal Cancer Preventive Effects of ONC201

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT05206357: Study of the Adverse Events and Change in Disease State of Pediatric Participants (and Young Adults Between the Ages of 18-25) With Relapsed/Refractory Aggressive Mature B-cell Neoplasms Receiving Subcutaneous (SC) Injections of Epcoritamab

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT05201248: A Study to Evaluate Adverse Events and Change in Disease Activity of Subcutaneous (SC) Epcoritamab As Monotherapy or Combined With Standard of Care Therapies in Adult Participants in China With B-Cell Non-Hodgkin Lymphoma

Study type: INTERVENTIONAL. Phase: PHASE1, PHASE2.

NCT05081609: A Study to Investigate Safety and Tolerability of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab and/or TransCon TLR7/8 Agonist or Other Anticancer Therapies in Adult Participants With Locally Advanced or Metastatic Solid Tumor Malignancies

Study type: INTERVENTIONAL. Phase: PHASE1, PHASE2.

NCT05019885: The Efficacy of a Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT04787848: Chronic Widespread Pain in HIV: Novel Mechanisms and Therapeutics

Study type: INTERVENTIONAL. Phase: NA.

NCT04166409: A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT04032470: Boston Scientific Registry of Deep Brain Stimulation for Treatment of Essential Tremor (ET)

Study type: OBSERVATIONAL. Phase: .

NCT03100149: A Study to Evaluate the Efficacy of Prasinezumab (RO7046015/PRX002) in Participants With Early Parkinson's Disease

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT02880618: BAROSTIM THERAPY™ in Heart Failure With Reduced Ejection Fraction

Study type: OBSERVATIONAL. Phase: .

NCT02824471: Sickle Cell Disease Biofluid Chip Technology (SCD BioChip)

Study type: OBSERVATIONAL. Phase: .

NCT01679132: BAROSTIM NEO Hypertension Pivotal Trial

Study type: INTERVENTIONAL. Phase: NA.

NCT00047996: Blood Collection for Research Related to Certain Diseases Involving Blood Vessels

Study type: OBSERVATIONAL. Phase: .

COPD Clinical Trial Pipeline Gains Momentum: 65+ Companies Lead the Charge in Pioneering New Treatments | DelveInsight