Pharmaceutical industry news

Perioperative methylprednisolone and early pulmonary function after minimally invasive valve surgery under ultra-fast-track cardiac anesthesia: a retrospectively registered randomized dose-comparison trial

Ultrasound facilitated catheter directed thrombolysis versus anticoagulation alone for intermediate risk pulmonary embolism: a systematic review and meta-analysis with trial sequential analysis

Longitudinal trajectories of questionnaire-derived health burden and clinical correlates among community-dwelling older adults: a retrospective cohort study in Deyang, China

Alarm Fatigue and Clinical Alarm Management in the Neonatal Intensive Care Unit: A Scoping Review of Quality Improvement Interventions, Outcome Metrics, and Implementation Lessons

Genomic analysis of <i>Campylobacter</i> animal clinical isolates illustrates clonal expansion of antimicrobial-resistant lineages and genomic proximity to human isolates

Clinical Impact of Haemophagocytic Lymphohistiocytosis Among Patients With <scp>HIV</scp> / <scp>AIDS</scp> and Disseminated Histoplasmosis in a Hyperendemic Region of Northeastern Brazil

Leadership Development Programmes for Clinical Nurses: A Systematic Review

Lived Experiences of People Who Have Undergone Liver Transplantation During the Post‐Transplant Recovery Period: A Meta‐Synthesis of Qualitative Studies

A Trial‐Level Benefit–Toxicity Mapping Framework for Adjuvant Therapy in Renal Cell Carcinoma: A Focused Review

From sensing to clinical translation: advances and challenges in wearable cuffless blood pressure monitoring

Association of Retinal Microvascular Density with Hemodynamic and Clinical Severity Markers in Pulmonary Arterial Hypertension

Lesson for the clinical nephrologist: acute kidney injury after conversion to belatacept, what went wrong?

Do Mendelian randomization findings for circulating proteins in polycystic kidney disease replicate? A two-stage, two-platform study

Cholinergic-targeted molecular hybrids: a renewed strategy for Alzheimer’s disease?

Vepdegestrant (ARV-471): pharmacokinetics, drug metabolism and clinical translation of an oral ERα-targeting PROTAC

Pharmacotherapeutic management of chronic pain in joint hypermobility and Ehlers-Danlos syndromes: a clinical perspective

From CYP450 pharmacogenomics to personalized medicine: clinical evidence, dosing guidelines, and future perspectives

Who drops out? Characteristics associated with dropout in a low-threshold physical activity intervention for people with mental illness – an exploratory analysis

Harnessing chemokines and nanocarriers to reprogram the tumor microenvironment

A clinical–biomechanical model of combined resection–recession surgery of the inferior rectus muscle in incomitant strabismus

Reducing State Anxiety in Older Adults Undergoing MRI: A Controlled Trial of a Multimedia Electronic Book Intervention

A Prospective Cohort Study of Clinical Outcomes, Tear Cytokines and Proteomic Profiles Following Insular Infraorbital Neurovascular Pedicle Labial Salivary Gland Transplantation for Severe Dry Eye Disease

Physicochemical rule-embedded generative modeling for constrained peptide therapeutics

Impact of a multi-component exercise program on circadian protein regulation and sleep quality in healthy females: a randomized controlled trial

Prevalence of drug-related hospital admissions and associated factors among chronic internal medicine wards in Wolaita Sodo University Comprehensive Specialized Hospital

A clinical multimodal vision language foundation model with fine-grain explainability

Sex- and frequency-dependent acute pharmacokinetic and pharmacodynamic effects of smoked cannabis: a randomized controlled trial

Supplemental Material for A Pilot Randomized Controlled Trial of a Physical Activity and Positive Affect Intervention After Metabolic and Bariatric Surgery

Electrochemical Analysis and Numerical Simulations for Geometry Improvement of Wearable Electrodes for Iontophoretic Drug Delivery

Robot-assisted gastrectomy for locally advanced gastric cancer and complex clinical scenarios: technical evolution, evidence gaps, and future directions

Waldenström macroglobulinemia: from frontline choice to sequencing informed by resistance biology

Special learning curves and clinical outcomes of full-endoscopic lumbar interbody fusion

Blood culture time to positivity corrected for delayed incubation start - a population-based study

Comparison of bone repair of advanced platelet-rich fibrin (A-PRF) and leukocyte- and platelet-rich fibrin (L-PRF) following the extraction of impacted third molars: a randomized clinical trial

AI-facilitated individualized nutritional guidance with ABC-structured prompts improves short-term dietary intake adequacy and patient-reported symptoms after gastrointestinal cancer surgery: a randomized controlled trial

SU5, a Stable Auraptene Analog, Ameliorates Metabolic Dysfunction‐Associated Steatohepatitis Through Modulation of the FXR Signaling Pathway

Giant Cervicothoracic Ganglioneuroma Misdiagnosed as Neurofibroma on Core Needle Biopsy: Transcervical Resection and Postoperative Neurological Sequelae: A Case Report

Cac3319 Inactivation Sustains Solventogenesis Through Proteomic and Phosphoregulatory Remodeling in <i>Clostridium acetobutylicum</i>

Fibroproliferative Remodeling of Immune‐Vascular Co‐Culture Spheroid Models in Response to Atherogenic Stimulation

Yeast Surface Display of Artificial Multienzyme Complexes for Enhanced Production of Rebaudioside M

Metabolic Remodelingof the NOG Pathway and Glyoxylate Cycle for High‐Yield L‐Homoserine Biosynthesis

Synthesis of a Stable Hydrophilic <i>trans</i> ‐Cyclooctene Amino Acid Unlocks Fast Bioorthogonal Click Chemistry for the Generation of Antibody‐Drug Conjugates by Genetic Code Expansion

Acute Endocrine Alterations After Traumatic Brain Injury and 6‐Month Functional Outcome

NCT07905560: A Study of Safety of SUN-0864 and How it is Processed by and Affects the Body in Healthy Adults and Healthy Adults Who Are Overweight or Obese.

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07905521: Effects of Art-Based Group Reminiscence Therapy on Resilience and Joy of Living in Older Adults

Study type: INTERVENTIONAL. Phase: NA.

NCT07904533: Efficacy and Safety of Minocycline Add-on in Patients With Neurosyphilis

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07904078: Demographic Data Collection in Healthcare

Study type: INTERVENTIONAL. Phase: NA.

NCT07903844: Effects of Different 432 Hz Auditory Stimuli on Physiological Stress Responses and Patient Satisfaction in Adults With Dental Anxiety During Restorative Treatment

Study type: OBSERVATIONAL. Phase: .

NCT07903740: Effects of Combined Pericapsular Nerve Group (PENG) and Lateral Femoral Cutaneous Nerve (LFCN) Blocks on Anaesthetic Requirements and Electroencephalographic Depth of Anaesthesia During Total Hip Arthroplasty: A Randomized Controlled Trial

Study type: INTERVENTIONAL. Phase: NA.

NCT07903649: A Randomized, Controlled Clinical Study on the Efficacy and Safety of Umbilical Cord Mesenchymal Stem Cells Combined With Standard Immunosuppressants in the Treatment of Children With Severe Aplastic Anemia

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07903441: Multiple Interventions With Distinct Anti-reservoir Activities in People on Antiretroviral Treatment

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07903090: Hepatectomy in Caroli Disease

Study type: OBSERVATIONAL. Phase: .

NCT07889778: Learning to Communicate Successfully Approach for Urdu Speaking Patients With Chronic Aphasia

Study type: INTERVENTIONAL. Phase: NA.

NCT07882160: Metabolic Impact of VLCPUFA-Rich Fish Oil: A Clinical Study on Omega-3 Index Enhancement in Healthy Individuals

Study type: INTERVENTIONAL. Phase: NA.

NCT07877259: Collection and Distribution of Blood Components From Healthy Donors for In Vitro Research Use

Study type: OBSERVATIONAL. Phase: .

NCT07845630: A Study in Healthy People to Compare How 2 Different Formulations of Vicadrostat / Empagliflozin Tablets Are Taken up in the Body

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07797140: The Effect of Acupuncture on Sarcopenia and Obesity in Patients With Sarcopenic Obesity.

Study type: INTERVENTIONAL. Phase: NA.

NCT07776691: A Study of Raludotatug Deruxtecan With or Without Bevacizumab as First-Line Maintenance Treatment in Non-HRD-Positive Advanced Ovarian Cancer (MK-5909-006, (ENGOT-ov102/GOG-3141/ REJOICE-Ovarian 04)

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07763431: Home-Use Dual-Light Antibacterial Photodynamic Therapy for Peri-Implant Mucositis in Full-Arch Implant Prostheses

Study type: INTERVENTIONAL. Phase: NA.

NCT07504458: Pivotal Open-label Phase 3 Clinical Study of QTX-2101 in Adult Patients With Acute Promyelocytic Leukemia

Study type: INTERVENTIONAL. Phase: PHASE3.