Pharmaceutical industry news

Integration of a clinical survival model into the KM-plotter to identify high-risk populations in breast cancer

The impacts of beta globin gene mutations and Xmn IGγ polymorphism (HBG2 c. -211 C > T) on the clinical features of Hb Eβ-thalassemia patients in Bangladesh

Maternal 6-valent group B Streptococcus vaccine in non-pregnant and pregnant females: a randomized phase 1/2 trial

Deep Learning Methods for Detection of Stroke for Neuropathology: Lessons learned from <i>In‑Vivo</i> Imaging to Digital Pathology

Autologous Peripheral Blood-Derived Stem Cells Combined with Platelet-Rich Plasma is Associated With Clinical and Radiological Improvement in Anterior Cruciate Ligament Ruptures—Preliminary Clinical and MRI Findings in 47 Consecutive Patients

Career Paths to Drug Development and Regulatory Science Through the U.S. Food and Drug Administration

Drug-specific differences in fatal adverse events among PARP inhibitors: a FAERS pharmacovigilance study

Impact of Press Needle Combining Breast Massage on Onset of Lactogenesis II in Post-Cesarean Mothers: A Randomized Controlled Trial

Efficacy and Safety of Zizhu Ointment for Wagner Grade 2 Diabetic Foot Ulcers: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Trial

Molecular characterization of β-lactamase genes and porin alterations in multidrug-resistant Gram-negative clinical isolates from Calabria, Southern Italy

Advancing in Personalization of Psychological, Indicated Preventive Interventions: A Randomized Controlled Trial in Adolescents at High-Risk of Developing Emotional Disorders

Genomic analysis of Streptococcus pyogenes emm1-type isolates reveals M1UK circulation and a genetically distinct Brazilian sublineage

Ivarmacitinib in patients with active ankylosing spondylitis: subgroup analysis based on key baseline features from a phase II/III trial

The impact of condylar fracture management on facial soft tissue changes and TMJ function: a 3D CBCT evaluation of open vs. closed reduction

Clinical and optical coherence tomography angiography-based risk factors for reduced retinal sensitivity in diabetic macular edema

The pre-operative physical component subscale of the 12-item Short Form Health Survey was the only factor associated with 2-year clinical outcome and satisfaction after hip abductor tendon repair

Population pharmacokinetic modeling of amisulpride drug interactions and a transporter binding analysis

Multi-omics Mendelian randomization identified adaptive immune response–related drug targets in psoriatic arthritis

Clinical Resource Use in Patients Undergoing Intradetrusor Abotulinum Toxin A Injections for Neurogenic Compared to Non‐Neurogenic Indications—The Potential for Compensation Inequities for Urologic and Urogynecologic Practices

An Engineered Multicellular Bacterial Network for Simultaneously Answering Multiple Computational Decision Problems

Randomized Clinical Trials Using a Hierarchical Composite Primary End Point

NCT07731659: Physical Activity Intervention for Individuals Newly Diagnosed With MS

Study type: INTERVENTIONAL. Phase: NA.

NCT07730151: Efficacy and Safety of Darolutamide Combined With Docetaxel and ADT as Neoadjuvant Therapy for Locally Advanced Prostate Cancer.

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07729852: Open-Label Access to ATH434 for Patients Who Completed Study ATH434-201 in France

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07729774: Spray and Stretch Technique Versus Strain Counter Strain in Patients With Non Specific Low Back Pain

Study type: INTERVENTIONAL. Phase: NA.

NCT07709494: A Phase 1a/1b Study to Investigate the Safety, Tolerability, Microbiological Response, and Pharmacokinetics of Inhaled Rev-56 in Adult Healthy Volunteers and Adult Non-cystic Fibrosis Bronchiectasis (NCFB) Patients With Chronic P. Aeruginosa

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07706673: A Scientific Evaluation of One or Two Doses of a Vaccine Against Human Papillomavirus: Long Term Follow Up of Gardasil9 Recipients in the ESCUDDO Study ("Estudio de Comparación de Una y Dos Dosis de Vacunas Contra el Virus de Papiloma Humano [VPH]")

Study type: OBSERVATIONAL. Phase: .

NCT07701369: Relevance of Artificial Intelligence-Assisted Echocardiography for Left Ventricular Ejection Fraction Assessment in Geriatric Patients

Study type: INTERVENTIONAL. Phase: NA.

NCT07692685: Pharmacokinetic Effect of Y-3 for Injection on Rosuvastatin Calcium Tablets in Healthy Participants

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07633288: A Clinical Trial Evaluating the Safety and Efficacy of AP1189 Versus Placebo as an add-on to Standard of Care in Participants With Respiratory Insufficiency Expected to be Caused by Infection With Respiratory Viruses

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07630961: Phase I Study of JFI447 [68Ga]Ga-DFC413 and Comparison to FFG233 [68Ga]Ga-NNS309 in Patients With Solid Tumors

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07596173: A Study on the Immune Response and Safety of a Combined Vaccine Against Diphtheria, Tetanus and Acellular Pertussis (dTpa) in Healthy Japanese Adolescents Aged 11 Years to <13 Years

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07507513: The Purpose of This Study is to Evaluate the Efficacy and Safety of 627 in the Treatment of UC

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07492498: Novel Model of Integrated Care of Older Patients With Atrial Fibrillation to Prevent Heart Failure in Rural China

Study type: INTERVENTIONAL. Phase: NA.

NCT07415057: Simulation on the Enhancement of Clinical Communication Competencies in Nursing Students

Study type: INTERVENTIONAL. Phase: NA.

NCT07360067: Prospective Cohort Study of Bachmann Bundle Versus Right Atrial Appendage Pacing: Impact on Atrial Cardiomyopathy Evaluated by Echocardiographic Parameters and Clinical Outcome

Study type: OBSERVATIONAL. Phase: .

NCT07272499: Orelabrutinib Plus Lisaftoclax and Rituximab in Untreated Mantle Cell Lymphoma With High-Risk Disease

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07270380: Antibiotic Device for Osteomyelitis of the Extremities Pivotal Trial - Genex With Gentamicin.

Study type: INTERVENTIONAL. Phase: NA.

NCT07192432: Gene Therapy for HER-Positive Cancer (SENTRY-HER2)

Study type: INTERVENTIONAL. Phase: PHASE1, PHASE2.

NCT07170527: Long-Term Outcomes and Post-Intensive Care Syndrome: Investigating the Associations Between Metabolic Signatures and Physical Functioning in Critically Ill Patients

Study type: OBSERVATIONAL. Phase: .

NCT06937931: A Study of IPN10200 for the Treatment of Cervical Dystonia in Adults

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT06825559: Evaluate PK & Safety of Saroglitazar in Subjects With Moderate Hepatic Impairment Due to Cholestatic Liver Disease

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT06510166: The Effect of Distraction Methods Used During Inhalation Therapy on Children's Fear and Anxiety: : Randomize Controlled Study

Study type: INTERVENTIONAL. Phase: NA.

NCT06484088: Study Brain Mechanisms of Frustration With Magnetoencephalography in Healthy Volunteers

Study type: INTERVENTIONAL. Phase: EARLY_PHASE1.

NCT06422338: A Rapid Triage Test to Improve Risk-stratification of Febrile Children (EChiLiBRiST, Clinical Trial 1, Outpatients)

Study type: INTERVENTIONAL. Phase: NA.

NCT06325696: H01 in Adults With Interstitial Lung Disease (The SOLIS Study)

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT06199232: Targeted Treatment Plus Tislelizumab and HAIC for Advanced CRCLM Failed From Standard Systemic Treatment

Study type: INTERVENTIONAL. Phase: NA.

NCT05911269: Feasibility of Virtual, Tailored, Music-Based Relaxation for Anxiety in Adolescent and Young Adult Cancer Survivors

Study type: INTERVENTIONAL. Phase: NA.

NCT05764746: Triple Artemisinin-based Combination Therapy for Delaying Drug Resistance Development - a Randomized Clinical Trial

Study type: INTERVENTIONAL. Phase: PHASE2, PHASE3.

NCT05282901: Efficacy and Safety of Pembrolizumab in Combination With Lenvatinib in Metastatic Uveal MElanoma Patients (PLUME)

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT05141682: Oral Azacitidine for the Treatment of Relapsed or Refractory T-cell Large Granular Lymphocytic Leukemia

Study type: INTERVENTIONAL. Phase: PHASE1, PHASE2.

NCT02877394: Use of a Squatting Assist Device in Patients With Constipation

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT02772003: DNA Vaccine Therapy in Treating Patients With Chronic Hepatitis C Virus Infection

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT02506933: Multi-antigen CMV-MVA Triplex Vaccine in Reducing CMV Complications in Patients Previously Infected With CMV and Undergoing Donor Hematopoietic Cell Transplant

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT02450851: Clinical and Genetic Evaluation of Individuals With Undiagnosed Disorders Through the Undiagnosed Diseases Network

Study type: OBSERVATIONAL. Phase: .

NCT02257892: Novel Genetic Disorders of the Immune System

Study type: OBSERVATIONAL. Phase: .

NCT02211768: Transformation of Plexiform Neurofibromas to Malignant Peripheral Nerve Sheath Tumors in Neurofibromatosis Type 1

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT01934660: Links Between Inflammation and Cardiometabolic Diseases

Study type: OBSERVATIONAL. Phase: .

NCT01621581: AAV2-GDNF for Advanced Parkinson s Disease

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT01306019: Lentiviral Gene Transfer for Treatment of Children Older Than Two Years of Age With X-Linked Severe Combined Immunodeficiency (XSCID)

Study type: INTERVENTIONAL. Phase: PHASE1, PHASE2.