Pharmaceutical industry news

Educational Attainment and Drug Firm Innovation

Randomized clinical trials and real-world clinical practice data for HR positive/HER2 negative metastatic breast cancer: a critical analysis of the evidence base. A review

Conversational AI Establishes Patient Understanding Before Clinician Contact: A Randomized Equivalence Trial (Preprint)

Inverted Takotsubo Cardiomyopathy Triggered by Corticosteroid Administration in a Patient with Undiagnosed Pheochromocytoma

Association of APOE gene expression with thyroid dysfunction, inflammation, and nitrosative stress in cardiometabolic syndrome: a case–control study

FDA Inspection Preparation

Humanitarian-Use Devices

Investigator Site File

Data Management

Clinical Trials Laws and Regulations

Investigational Drug Compounding vs. Manufacturing

MedWatch

Site Initiation and Site Initiation Visit (SIV) Procedures

Introduction

Psychological outcomes and intention to use following an 8-week virtual reality tennis training programme: a randomised controlled trial with exploratory mediation analysis

Accelerated biological aging mediates the associations of plasma lactate and the glucose-lactate index with MASLD: a prospective cohort study

Multi-omics analysis reveals MICB promotes cerebral atherosclerosis through FTMT suppression in NK and plasma cells

Development and validation of the analytical method for determination of residual solvents (2-propanol and n-hexane) in the drug substance Inosine Pranobex

Construction of a comprehensive competency evaluation index system for clinical nursing instructors based on a multifaceted feedback model

Prenatal ultrasound findings associated with intrauterine CMV infection: a multicenter retrospective analysis of clinical and sonographic features

Novel blood lncRNA biomarkers associated with clinical severity and specific cognitive dimensions in Alzheimer's disease

Global, Regional, and National Burden of Major Depressive Disorder From 1990 to 2021: Analysis of Data From GBD 2021

Oral Semaglutide for Alcohol Use Disorder: A Randomized Clinical Trial

Supplementary Table S10 from Clinical Validation of Tissue and Liquid Companion Diagnostics for <i>BRAF</i> V600E Detection in Non–Small Cell Lung Cancers from the PHAROS Study

Supplementary Table S11 from Clinical Validation of Tissue and Liquid Companion Diagnostics for <i>BRAF</i> V600E Detection in Non–Small Cell Lung Cancers from the PHAROS Study

Supplementary Table S3 from Clinical Validation of Tissue and Liquid Companion Diagnostics for <i>BRAF</i> V600E Detection in Non–Small Cell Lung Cancers from the PHAROS Study

Supplementary Table S9 from Clinical Validation of Tissue and Liquid Companion Diagnostics for <i>BRAF</i> V600E Detection in Non–Small Cell Lung Cancers from the PHAROS Study

Table 3 from Clinical Validation of Tissue and Liquid Companion Diagnostics for <i>BRAF</i> V600E Detection in Non–Small Cell Lung Cancers from the PHAROS Study

Bowel dysfunction (LARS) and quality of life after chemoradiotherapy and local excision versus total mesorectal excision in T2–T3ab, N0, M0 rectal cancer: the TAUTEM randomized clinical trial

Hepatic Responses as Potential Biomarkers of Idiosyncratic Drug Reaction Risk

Clinical justification for osteoporosis investigation: transitioning from opportunistic to diagnostic referrals from alternative forms of imaging

Mechanisms of change in mobile app-delivered acceptance and commitment therapy for posttraumatic stress disorder in China: a secondary analysis of a randomized controlled trial

Diagnosis of traumatic diaphragmatic injury remains a clinical challenge – Brief report

Lactate/AARS1-mediated H3K18la in the modulation of ACSL4 transcription to trigger ferroptosis in myocardial ischemia reperfusion

Clinical and biomechanical recovery trajectories during anti-gravity treadmill-assisted rehabilitation after complex lower-limb articular fractures: a prospective pilot cohort study

Cognitive-behavioral therapy as an adjunct to physical management of chronic painful temporomandibular disorders: A DC/TMD Axis II guided randomized controlled trial

Effects of psychosocial stress on opioid self-administration in healthy participants: a randomized, placebo-controlled crossover trial

Development and pilot evaluation of an electronic trigger-based surveillance model for sedative-hypnotic drug misuse in a tertiary hospital

Invasive mold infection in pediatric acute lymphoblastic leukemia—a detailed analysis of the clinical trial AIEOP-BFM ALL2009

Effect of ocean sounds played during retinopathy of prematurity examinations on physiology, pain, and comfort levels: a randomized controlled trial

To help children with rare diseases, we must solve drug delivery

A Randomised Controlled Trial to Study the Use of Large Language Models Prompt Engineered with Socratic Methods on the Impact of Medical Students’ Learning

Signals of Venous Thromboembolism Risk from Drug–Drug Interactions Involving Benzodiazepines and Other Sedative Hypnotics: Self-Controlled Case Series Analyses

Assessment of Prevalence and Clinical Profile and Risk Factors for Pregnancy-Related Acute Kidney Injury in a Tertiary Care Hospital in India

ERAP1 rs27038 Polymorphism and IL-17A in Radiographic Axial Spondyloarthritis: A South Indian Case–Control Study

Sexual Myths and Self-Consciousness in Women: A Randomized Controlled Trial on the Power of Education

Comparison of accelerated MRI protocol approaches for clinical assessment of the knee

Comparative Clinical and Molecular Epidemiology of Norovirus in Hospitalized Gastroenteritis Cases, Western India (2013‐2023)

Engineering Extracellular Vesicles: Strategies for Functional Modification and Clinical Translation

Intelligent Automation Improved Efficiency in Pharmacovigilance Safety Signal Assessment

Comment on “Association of Ticagrelor Metabolic SNPs With Adverse Drug Reactions in Patients With Acute Coronary Syndrome”

In adults with low back pain with Modic type 1 changes and disc herniation on magnetic resonance imaging (MRI), what are the benefits and harms of antibiotic therapy compared with placebo?

Pharmacometric evaluation of pre‐referral rectal artesunate in children with severe malaria

NCT07735065: Tumor-Specific T-Cells (cCTL:GL01) for Advanced Gastrointestinal Cancer

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07734727: Adaptation and Testing of a Novel Text-based Tobacco Cessation and Education Intervention in Kenyan Emergency Department Patients

Study type: INTERVENTIONAL. Phase: NA.

NCT07734506: RELATIONSHIP BETWEEN ULTRASONOGRAPHIC QUADRICEPS MUSCLE THICKNESS AND SARCOPENIA MARKERS (HANDGRIP STRENGTH, SARC-F) AND KINESIOPHOBIA IN STROKE PATIENTS

Study type: OBSERVATIONAL. Phase: .

NCT07734389: Genetic Assessment of Breast Cancer Risk in Women in the DORA Programme

Study type: INTERVENTIONAL. Phase: NA.

NCT07734285: Detection of Cardiac Amyloidosis Using Right Ventricular Sensing Amplitude in Patients With Left Ventricular Hypertrophy

Study type: INTERVENTIONAL. Phase: NA.

NCT07733882: Study on Clinical and Pathological Features of Primary Biliary Cholangitis and Risk Factors Related to Disease Progression

Study type: OBSERVATIONAL. Phase: .

NCT07733583: Pelvic Floor Physical Therapy and Exercise for Women With Endometriosis and Chronic Pelvic Pain

Study type: INTERVENTIONAL. Phase: NA.