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PharmaRadar360

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Pharmaceutical industry news

Fresh coverage across pharma, biotech, medtech, research, approvals, and market-moving developments.

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🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

SSGJ-613 Alleviates Pain and Reduces the Risk of Acute Flares in Patients With Gout: A Randomized, Double-Blind, Phase II Study.

Europe PMCOriginal source
🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

TrxR Inhibition and Nrf2-FOXO3 Modulation by Repurposed Drugs: A Redox Strategy to Reverse Cancer Multidrug Resistance.

Europe PMCOriginal source
🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

Effects of Bifidobacterium animalis Subsp. Lactis CP-9 on Gut Microbiota and Immune Functions in Healthy Infants.

Europe PMCOriginal source
🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

Pragmatic Two-Stage Design for Clinical Trials With Treatment Selection.

Europe PMCOriginal source
🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

A Simulation-Based Assessment of Dosage Regimen Appropriateness for Multiple Myeloma Medicines Reflecting Demographic and Ethnic Differences.

Europe PMCOriginal source
🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

Pharmacological Insights and Clinical Challenges of Wenxin Keli in Arrhythmia Treatment.

Europe PMCOriginal source
🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

Safety and Pharmacokinetics of Olamkicept Doses up to 2400 mg in Healthy Japanese Men: Phase I, Randomized, Placebo-Controlled, and Double-Blind Trial.

Europe PMCOriginal source
🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

Vobramitamab duocarmazine, an anti-B7-H3 antibody-drug conjugate, in patients with advanced solid tumors: Final results of a phase 1 cohort expansion.

Europe PMCOriginal source
🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

Does Increasing Sample Size Inevitably Lead to Statistical Significance? Insights From a Monte Carlo Simulation Study for Medical Research Design.

Europe PMCOriginal source
🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

Safety and Pharmacokinetics of Single and Multiple Ascending Doses of Olamkicept up to 2400 mg in Healthy Men: Phase I, Randomized, Placebo-Controlled, and Double-Blind Trial.

Europe PMCOriginal source
🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

Hybrid Response Surface-Machine Learning Optimization of Doxorubicin-Loaded Chitosan Nanoparticles.

Europe PMCOriginal source
🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

Larotrectinib in TRK fusion differentiated thyroid carcinoma: updated trial data.

Europe PMCOriginal source
🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

A Prospective Observational Study of Anamorelin During Chemoimmunotherapy in Non-Small Cell Lung Cancer With Cachexia (SPIRAL-ANA).

Europe PMCOriginal source
🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

Dexamethasone Versus Placebo in Comatose Survivors of Out-of-Hospital Cardiac Arrest: Study Protocol for a Multicenter Randomized Comparison Within the Danish Out-of-Hospital Cardiac Arrest Trial (DANOHCA).

Europe PMCOriginal source
🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

Prophylactic Olanzapine Versus Placebo in Comatose Survivors of Out-of-Hospital Cardiac Arrest: Protocol for a Multicenter Randomized Comparison Within the Danish Out-of-Hospital Cardiac Arrest (DANOHCA) Trial.

Europe PMCOriginal source
🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

To Cluster or Not to Cluster? A Comparison of Approaches to Targeting Type 2 Diabetes Glucose-Lowering Therapy in the TriMaster Crossover Trial.

Europe PMCOriginal source
🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

Weight-Lowering Drugs and Natural Female Fertility-A Systematic Review and Meta-Analysis.

Europe PMCOriginal source
🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

FDA Announces Efforts to Implement Real-Time Clinical Trial Reporting.

Europe PMCOriginal source
🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

Differential effects of sevoflurane versus propofol on calmodulin expression in breast cancer patients.

Europe PMCOriginal source
🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

The mechanisms of myricetin and quercetin in regulating miRNA-140 and MMP/TIMP signaling pathway in osteoarthritis treatment.

Europe PMCOriginal source
🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

HLHRUXO: a prospective trial of a ruxolitinib-containing regimen for children with hemophagocytic lymphohistiocytosis.

Europe PMCOriginal source
🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

Interleukin 6 as a Treatment Target for Depression: A Proof-of-Concept Randomized Clinical Trial.

Europe PMCOriginal source
🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

Pamufetinib (TAS-115) for chronic fibrosing interstitial lung diseases with a progressive phenotype: a double-blind, multicenter, phase 2b clinical trial.

Europe PMCOriginal source
🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

Efficacy and safety of GS1-144, a novel neurokinin 3 receptor antagonist, for moderate-to-severe vasomotor symptoms associated with menopause in Chinese women: a randomized, double-blind, placebo-controlled phase 2 trial.

Europe PMCOriginal source
🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

Accelerating the Clinical Translation of Antibody-Drug Conjugates in Pancreatobiliary Cancers: A Comprehensive Clinical Trial Landscape Analysis Based on the Trialtrove Clinical Intelligence Database.

Europe PMCOriginal source
🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

Phenotype Variability in Interstitial Cystitis Clinical Trial Recruitment.

Europe PMCOriginal source
🇪🇺Researcheuropepmc.orgTier 2 · Direct publisher

Synergistic innovation in organ-on-a-chip and organoid technologies: reshaping the future of disease modeling, drug development, and precision medicine.

Europe PMCOriginal source
🌍Researchdoi.orgTier 1 · Research record

Incidentally Detected Dual-feeder Pulmonary Arteriovenous Malformation Mimicking a Pulmonary Mass on CT: A Case Report

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🌍Researchdoi.orgTier 1 · Research record

A Case of Lupus Erythematosus Panniculitis of the Abdominal Wall: Imagingcytopathological Association

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🌍Researchdoi.orgTier 1 · Research record

Magnesium Sulphate versus Fentanyl as an Adjuvant to Levobupivacaine in Ultrasoundguided Supraclavicular Brachial Plexus Block: A Randomised Controlled Study

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🌍Researchdoi.orgTier 1 · Research record

Inflammatory cytokines, autoantibodies and salivary gland function in Sjögren’s syndrome: Effects of T. wilfordii as Hook F medical wine and tripterygium glycosides tablets

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🌍Researchdoi.orgTier 1 · Research record

الاسهام النسبي لاضطراب صورة الجسم والتنمر في التنبؤ برهاب الجيلوتوفوبيا(رهاب السخرية) لدى البدينات المترددات على مراكز علاج السمنة (دراسة سيكومترية- كلينيكية) bullying in predicting gelotophobia (fear of ridicule) among obese women attending obesity treatment centers (psychometric-clinical study)

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🌍Researchdoi.orgTier 1 · Research record

Hemodynamic Response to Intubation With 4 Different Laryngoscopes in Coronary Artery Bypass Graft Surgery: A Randomized Trial

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🌍Researchdoi.orgTier 1 · Research record

Questioning child and adolescent sex abuse victims at trial: A gender-based investigation.

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🌍Researchdoi.orgTier 1 · Research record

Effect of transcript length, temperature, and lyophilization on mRNA-lipid nanoparticle stability

CrossrefOriginal source
🌍Researchdoi.orgTier 1 · Research record

Immunogenicity and safety of Papilloguard® 4, the first quadrivalent HPV vaccine combined with adjuvant system 04, versus Gardasil® in healthy 15–25-year-old individuals: a phase III, randomized, double-blind, non-inferiority trial

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🌍Researchdoi.orgTier 1 · Research record

Broad-spectrum antibiotic prophylaxis for pancreatoduodenectomy: Assessment of early adoption of randomized trial data

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🌍Researchdoi.orgTier 1 · Research record

Looking through the cracks: vulnerabilities and deprivation in the Brazilian open drug scenes

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🌍Researchdoi.orgTier 1 · Research record

Pregnancy outcomes following Eslicarbazepine acetate exposure in women with epilepsy: A global safety database analysis from clinical development to 16 years of post-marketing experience

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🌍Researchdoi.orgTier 1 · Research record

Targeting pulmonary vascular–alveolar coupling in bronchopulmonary dysplasia: Therapeutic mechanisms and translational prospects of extracellular vesicle-based drug delivery

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🌍Researchdoi.orgTier 1 · Research record

How health professionals navigate diagnostic uncertainty in clinical practice: A rapid scoping review

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🌍Researchdoi.orgTier 1 · Research record

Reframing immunonutrition evidence in clinical practice: A call for standardised mechanistic and outcome measures

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🌍Researchdoi.orgTier 1 · Research record

Metabolic, adherence, and sustainability outcomes of plant-based low-carbohydrate and ketogenic diets: A systematic review of clinical evidence

CrossrefOriginal source
🌍Researchdoi.orgTier 1 · Research record

Biomarker Testing Among Patients With Nonsquamous NSCLC Across Three Time Periods and Three Testing Platforms—A Brief Report

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🌍Researchdoi.orgTier 1 · Research record

Letter to the Editor re: "Clinical prediction modeling of baseline differential renal function based on ultrasound in congenital unilateral ureteropelvic junction obstruction"

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🌍Researchdoi.orgTier 1 · Research record

Interdisciplinary intervention (GAIN) vs. enhanced usual care for reducing severe post-concussion symptoms in adults 2–4 months post-injury: A stepped wedge cluster randomised controlled trial

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🌍Researchdoi.orgTier 1 · Research record

Neighborhood socioeconomic deprivation is associated with operative spinal neoplasms: a cross-sectional analysis of 1,038 patients

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🌍Researchdoi.orgTier 1 · Research record

Assessing the Assessors: Comparative performance of frailty and nutritional metrics in predicting 30-Day morbidity and mortality after cranial neurosurgery

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🌍Researchdoi.orgTier 1 · Research record

Multi-strain Clostridioides difficile infection: Increased detection and clinical implications

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🌍Researchdoi.orgTier 1 · Research record

0512 Guselkumab for the treatment of guttate and plaque psoriasis: A prospective trial

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🌍Researchdoi.orgTier 1 · Research record

Fabrication and Characterization of buccal dissolving microneedles for the potential management of Parkinson Disease

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🌍Researchdoi.orgTier 1 · Research record

Recent advances on thermoresponsive hydrogels in ophthalmology with specific focus on their applications in dry eye disease management: Current status and future prospective

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🌍Researchdoi.orgTier 1 · Research record

Thyroid cancer and double-strand DNA break repair: The potential role of the MRN complex pathogenic variants

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🌍Researchdoi.orgTier 1 · Research record

Letter to the editor: “Clinical outcomes of early fast compared to slow sodium correction rate in adults with severe hypernatremia: A comparative effectiveness study”

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🌍Researchdoi.orgTier 1 · Research record

Impact of cyst maturity on drug resistance assays in Acanthamoeba Genotype T4

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🌍Researchdoi.orgTier 1 · Research record

Anaphalis margaritacea ethanol extract exhibits potent anti-Trichinella spiralis activity via mitochondrial dysfunction and host tissue protection

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🌍Researchdoi.orgTier 1 · Research record

Postoperative effects of horizontal platelet-rich fibrin after impacted third molar extraction: a randomized controlled trial

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🌍Researchdoi.orgTier 1 · Research record

Ion valency–driven control of network architecture and tissue-level drug transport in protein-derived hydrogels

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🌍Researchdoi.orgTier 1 · Research record

TLR4 knockout ameliorates acute LPS-sensitized tolvaptan-induced idiosyncratic liver injury by disrupting drug metabolism, inflammation, and bile acid homeostasis

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🌍Researchdoi.orgTier 1 · Research record

CD20-targeted immunotherapies in B-cell malignancies: mechanistic and clinical advances

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