Pharmaceutical industry news

NIH award: Longitudinal study of metal mixtures and the developmental origins of adolescent risk-taking

Recipient: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI. Award amount: 155074.

NIH award: I4C 2.0: Immunotherapy for Cure

Recipient: BETH ISRAEL DEACONESS MEDICAL CENTER. Award amount: 4653643.

NIH award: Persistence of HIV-specific B cells after long-term antiretroviral therapy in early treated Thai children

Recipient: OREGON HEALTH & SCIENCE UNIVERSITY. Award amount: 236444.

NIH award: Structure-based Sieve Analysis to Understand the Impact of Antibody-Mediated Immunity

Recipient: HENRY M. JACKSON FDN FOR THE ADV MIL/MED. Award amount: 317272.

NIH award: A Pseudovirus Nanoparticle-Based Mpox Vaccine for Oral Immunization

Recipient: CINCINNATI CHILDRENS HOSP MED CTR. Award amount: 243000.

NIH award: Characterizing the impact of Hlb expression on the ability of MRSA to evade human PMN responses

Recipient: MONTANA STATE UNIVERSITY - BOZEMAN. Award amount: 217500.

NIH award: Enhancing glioblastoma virotherapy with a bioluminescent Zika virus NS5 sensor and integrated gene circuit

Recipient: CENTRAL MICHIGAN UNIVERSITY. Award amount: 144641.

NIH award: CTSA Predoctoral T32 at the University of Florida: CTS Team Training

Recipient: UNIVERSITY OF FLORIDA. Award amount: 297919.

NIH award: Transcriptional regulation of chamber selective gene expression

Recipient: BOSTON CHILDREN'S HOSPITAL. Award amount: 809323.

NIH award: IL21R signaling in CD4 T cells converts transient KRASi responses to long term remissions

Recipient: DANA-FARBER CANCER INST. Award amount: 643414.

NIH award: Building a unified framework for understanding bacterial gene regulation and chromosomal architecture

Recipient: UNIVERSITY OF MICHIGAN AT ANN ARBOR. Award amount: 407009.

NIH award: Unveiling Functional Roles of Apical Surface Interactions Between Opposing Cell Layers

Recipient: UNIVERSITY OF WASHINGTON. Award amount: 441250.

NIH award: Engineering Immunostimulatory Spherical Nucleic Acids for B cell adoptive therapy

Recipient: NORTHWESTERN UNIVERSITY. Award amount: 660525.

NIH award: FlyBand-Peds: Evaluating Biomechanics of Integrated Exoskeleton Footwear for Pediatric Charcot-Marie-Tooth Disease

Recipient: RESULTS GROUP. Award amount: 305904.

NIH award: A Designed Host Defense Peptide to Prevent Burn Infections

Recipient: RIPTIDE BIOSCIENCE, INC.. Award amount: 1000000.

NIH award: Investigating the origin and functional impact of "hidden" structural variants in rare genetic diseases

Recipient: PACIFIC NORTHWEST RESEARCH INSTITUTE. Award amount: 1231446.

Drug label update: Potassium Chloride

Official structured record identifier: f9965f73-e189-423f-bd10-c4a0ed12b485.

Drug label update: Dexamethasone sodium phosphate

Official structured record identifier: c6f2563b-5a39-48bf-bcfe-71dd417bd970.

Drug label update: Ibuprofen and famotidine

Official structured record identifier: 9f5de6af-e555-4efd-a3ed-b72c34c051b6.

Drug label update: unspecified product

Official structured record identifier: 31be21c3-984b-de50-e063-6394a90a86ff.

Drug label update: CAFFEINE CITRATE

Official structured record identifier: 279a43b8-9ff5-4792-ac19-441f3fa49269.

Exposure-Response Relationship of Dostarlimab in Primary Advanced/Recurrent Endometrial Cancer: Results From Interim Analysis 2 of Part 1 of the RUBY Trial.

Open-Label, Balanced, Randomized, Single-Dose, Three-Treatment, Three-Sequence, Three-Period, Three-Way Crossover Oral Bioequivalence Study of Desmopressin Acetate Oral Solution.

The Economics Of Orphan Blockbuster Drug Development.

Antithrombotic strategy according to age in patients with atrial fibrillation and drug-eluting stents: a post hoc analysis of the ADAPT AF-DES randomised trial.

Comment on "Olaparib combined with abiraterone in HRR-mutated metastatic hormone-sensitive prostate cancer: a single-arm phase II trial".

Cardiovascular safety of psilocybin in psychiatric practice: a narrative review.

From Small Data to Big Decisions: How Clinical Pharmacology Shapes Rare Disease Development.

Refinement of Operating Characteristics for Model-Based TGI Metrics Decision Support to Ungate a Pivotal Trial in Oncology.

A Bayesian Optimal Adaptive Clinical Trial Design for Sequentially Integrated Therapies.

Safety, Tolerability, Pharmacokinetics, Food Effect of Ribitol, and Its Effect on QTcF in Healthy Adults: First-in-Human, Randomized, Double-Blind (Sponsor Unblinded), Placebo-Controlled Studies.

Innovative Clinical Pharmacology, Modeling, and Simulation Strategies for Accelerating Rare Disease Drug Development.

SSGJ-613 Alleviates Pain and Reduces the Risk of Acute Flares in Patients With Gout: A Randomized, Double-Blind, Phase II Study.

TrxR Inhibition and Nrf2-FOXO3 Modulation by Repurposed Drugs: A Redox Strategy to Reverse Cancer Multidrug Resistance.

Effects of Bifidobacterium animalis Subsp. Lactis CP-9 on Gut Microbiota and Immune Functions in Healthy Infants.

Pragmatic Two-Stage Design for Clinical Trials With Treatment Selection.

A Simulation-Based Assessment of Dosage Regimen Appropriateness for Multiple Myeloma Medicines Reflecting Demographic and Ethnic Differences.

Pharmacological Insights and Clinical Challenges of Wenxin Keli in Arrhythmia Treatment.

Safety and Pharmacokinetics of Olamkicept Doses up to 2400 mg in Healthy Japanese Men: Phase I, Randomized, Placebo-Controlled, and Double-Blind Trial.

Vobramitamab duocarmazine, an anti-B7-H3 antibody-drug conjugate, in patients with advanced solid tumors: Final results of a phase 1 cohort expansion.

Does Increasing Sample Size Inevitably Lead to Statistical Significance? Insights From a Monte Carlo Simulation Study for Medical Research Design.

Safety and Pharmacokinetics of Single and Multiple Ascending Doses of Olamkicept up to 2400 mg in Healthy Men: Phase I, Randomized, Placebo-Controlled, and Double-Blind Trial.

Hybrid Response Surface-Machine Learning Optimization of Doxorubicin-Loaded Chitosan Nanoparticles.

Larotrectinib in TRK fusion differentiated thyroid carcinoma: updated trial data.

A Prospective Observational Study of Anamorelin During Chemoimmunotherapy in Non-Small Cell Lung Cancer With Cachexia (SPIRAL-ANA).

Dexamethasone Versus Placebo in Comatose Survivors of Out-of-Hospital Cardiac Arrest: Study Protocol for a Multicenter Randomized Comparison Within the Danish Out-of-Hospital Cardiac Arrest Trial (DANOHCA).

Prophylactic Olanzapine Versus Placebo in Comatose Survivors of Out-of-Hospital Cardiac Arrest: Protocol for a Multicenter Randomized Comparison Within the Danish Out-of-Hospital Cardiac Arrest (DANOHCA) Trial.

To Cluster or Not to Cluster? A Comparison of Approaches to Targeting Type 2 Diabetes Glucose-Lowering Therapy in the TriMaster Crossover Trial.

Weight-Lowering Drugs and Natural Female Fertility-A Systematic Review and Meta-Analysis.

FDA Announces Efforts to Implement Real-Time Clinical Trial Reporting.

Differential effects of sevoflurane versus propofol on calmodulin expression in breast cancer patients.

The mechanisms of myricetin and quercetin in regulating miRNA-140 and MMP/TIMP signaling pathway in osteoarthritis treatment.

HLHRUXO: a prospective trial of a ruxolitinib-containing regimen for children with hemophagocytic lymphohistiocytosis.

Interleukin 6 as a Treatment Target for Depression: A Proof-of-Concept Randomized Clinical Trial.

Pamufetinib (TAS-115) for chronic fibrosing interstitial lung diseases with a progressive phenotype: a double-blind, multicenter, phase 2b clinical trial.

Efficacy and safety of GS1-144, a novel neurokinin 3 receptor antagonist, for moderate-to-severe vasomotor symptoms associated with menopause in Chinese women: a randomized, double-blind, placebo-controlled phase 2 trial.

Accelerating the Clinical Translation of Antibody-Drug Conjugates in Pancreatobiliary Cancers: A Comprehensive Clinical Trial Landscape Analysis Based on the Trialtrove Clinical Intelligence Database.

Phenotype Variability in Interstitial Cystitis Clinical Trial Recruitment.

Synergistic innovation in organ-on-a-chip and organoid technologies: reshaping the future of disease modeling, drug development, and precision medicine.

Incidentally Detected Dual-feeder Pulmonary Arteriovenous Malformation Mimicking a Pulmonary Mass on CT: A Case Report