Pharmaceutical industry news

Synergism in drug combination of new tuberculosis antibiotics for drug-resistant <i>Mycobacterium tuberculosis in vitro</i>

Types I, II, V, and VI secretion system genes in clinical uropathogenic <i>Escherichia coli</i> associate with antibiotic susceptibility, biofilm formation, and persister cells

Advancement of LAMP technologies for rapid and accurate diagnosis of infectious diseases

The Effect of Orthodontic Tooth Movement on Intrabony Periodontal Defects After Guided Tissue Regeneration. Part <scp>II</scp> : The Evaluation of Clinical and Radiological Parameters in a Randomised Controlled Clinical Trial

Nucleos(t)ide withdrawal vs Nucleos(t)ide withdrawal with adjuvant pegylated-interferon in HBeAg-negative hepatitis B virus infection (NUC-B Trial)

Letter to the Editor: A Novel Classification System for Fifth Metatarsal Base Fractures Is Reliable and Clinically Validated

Clinical Decision Support to Reduce Opioid Prescribing at Discharge for Inpatients Undergoing Surgery (LESS Study): An Interrupted Time Series Analysis

Cerebral aspergillosis under ibrutinib therapy: clinical features and management challenges

Transitioning AI-based sperm assessment from proof-of-concept to clinical practice

Latent profiles of social isolation and loneliness and their associations with inflammation and clinical outcomes in older patients with heart failure: A prospective longitudinal study

Fear of clofazimine-induced skin discoloration as a barrier to leprosy treatment: urgent need for alternative therapeutic options

The Social Insensitivity of Clinical Delusions

The Social Determinants and Focus of Clinical Delusions

Individualistic Accounts of Clinical Delusions

Clinical and genetic risk factors for anthracycline‑induced cardiotoxicity in Chinese early‑stage breast cancer patients: a candidate gene study

Ubiquitin family as novel protein partners for molecular glues

Uterine artery bulldog clamping versus tourniquet for reducing blood loss in open myomectomy: a randomized controlled trial

The microbiological spectrum and clinical course of adolescents and adults with peritonsillar abscesses

The landscape and plasticity of transposable element expression in an adult stem cell of high physiological and clinical significance

Global trends in artificial intelligence applications in medical imaging and implications for clinical practice

Hepatic sarcoidosis presenting with portal hypertension without histologically established cirrhosis and reticular hepatic imaging features

Identification of novel diagnostic markers in progressive bone mineral density loss via serum proteomics analysis using orbitrap mass spectrometry

Oxidative Stress and IL-36α–Mediated Inflammation in Osteoarthritis: Association with Tryptophan–Kynurenine Metabolism

Rapid antimicrobial susceptibility testing: bridging commercial platforms and emerging technologies toward clinical implementation

Comparative analysis of supervised machine learning algorithms for transdermal drug delivery in brain disorders

Reducing time-to-result in bloodstream infections: comparative evaluation of VITEK® REVEAL™ and QuickMIC® for rapid phenotypic antimicrobial susceptibility testing

Association of urinary albumin-to-creatinine ratio with all-cause and cardiovascular disease mortality risk in patients with osteoarthritis: a prospective cohort study

Efficacy and safety of add-on topiramate vs. metformin on cardiometabolic profile in patients of schizophrenia on atypical antipsychotics with metabolic syndrome: an active-controlled, rater-blinded, parallel-design randomized controlled trial

Investigating changes in the blood-brain barrier in schizophrenia spectrum disorders: design and methodology of a longitudinal dynamic contrast-enhanced MRI study

A mortality model for relapsed or refractory multiple myeloma: emulation of subjective life expectancy criteria from a clinical trial in real-world data

Subtractive proteomics-assisted putative drug target and inhibitor identification: a study based on six Candida species

HHV‐8 Infection in Solid‐Organ Transplant—Pathogenesis, Epidemiology, Clinical Manifestations and Management

What drives prolonged hospital stays in schizophrenia‐spectrum disorders? A Canadian tertiary care review

Tongue Grooving During Drug‐Induced Sleep Endoscopy: A Novel Tool to Evaluate the Airway

Consensus recommendations for technical standardization of flow cytometric measurable residual disease assessment in <scp>B</scp> ‐cell acute lymphoblastic leukemia: A report from <scp>The Cytometry Society, India</scp>

Drug Repurposing in Sickle Cell Disease: Evaluating Imatinib as a Therapeutic Candidate

NCT07746141: A First-in-Human Study Investigating BG-85738 Alone or in Combination With Other Antitumor Agents in Patients With Advanced or Metastatic Solid Tumors With Rat Sarcoma Virus (RAS) Mutations

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07745790: Safety and Efficacy of Multimodal Thermal Therapy (MTT) Combined With KRAS G12V mRNA Vaccine, S-1, and Sintilimab in Patients With Metastatic Pancreatic Cancer

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07745491: Pneumonia After Cardiovascular Surgery With an Artificial Intelligence

Study type: OBSERVATIONAL. Phase: .

NCT07745322: Spatial MSC Index for Predicting Anti-PD-1 Efficacy in Esophageal Cancer

Study type: OBSERVATIONAL. Phase: .

NCT07745010: Radicle Energy™ DNB: A Study Assessing the Impact of Health and Wellness Products on Fatigue and Related Health Outcomes

Study type: INTERVENTIONAL. Phase: NA.

NCT07744958: RESTORE-BLADDER (REgistry on STrategies for Organ pREservation in Muscle-invasive BLADDER Cancer)

Study type: OBSERVATIONAL. Phase: .

NCT07744295: Preoperative Anxiety and Depression Among Older Chinese Patients

Study type: OBSERVATIONAL. Phase: .

NCT07743541: Study of TUB-040 in Patients With Recurrent or Progressive Uterine Cancer After Chemotherapy and Immune Therapy

Study type: INTERVENTIONAL. Phase: PHASE1, PHASE2.

NCT07743528: A Prospective, Multicenter, Two-cohorts, Single Arm Study Evaluating Safety, Effectiveness and Performance of Angimis Atherectomy System for the Treatment of Non-crossable and/or Non-dilatablE Lesions in CorONary Arteries Disease (NEON Study).

Study type: INTERVENTIONAL. Phase: NA.

NCT07728890: Effect of Box Breathing Exercise on Anxiety, Pain, and Pulmonary Function Tests in Patients Undergoing Colonoscopy

Study type: INTERVENTIONAL. Phase: NA.

NCT07724197: Pulsatile Electrical Impedance Tomography for Diagnosis and Monitoring of Acute Pulmonary Embolism

Study type: OBSERVATIONAL. Phase: .

NCT07642765: EASIX Score and Post-Induction Hypotension in Frail Patients Undergoing Non-Cardiac Surgery

Study type: OBSERVATIONAL. Phase: .

NCT07587242: A Phase 3 Study to Evaluate the Safety and Efficacy of AOC 1044 (Also Referred to as Delpacibart Zotadirsen) in Participants With DMD With Gene Mutations Amenable to Exon 44 Skipping

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07539311: Study to Assess the Efficacy and Safety of Rina-S in Participants With Advanced Gastrointestinal (GI) Cancers

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07409194: The Effect of Acupressure on Hyperbilirubinemia in Newborns: A Randomized Controlled Trial

Study type: INTERVENTIONAL. Phase: NA.

NCT07408089: Study of the Kinesin Oral Molecular Degrader BBI-940 in Subjects With Advanced or Metastatic Breast Cancer

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07306559: A Study to Test How Well Different Doses of BI 3820768 Are Tolerated by People With Advanced Cancer (Solid Tumours)

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07226206: A Gene Therapy Study of SPK-8011QQ in Adults With Severe or Moderately Severe Hemophilia A

Study type: INTERVENTIONAL. Phase: PHASE1, PHASE2.

NCT07225686: Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea on Positive Airway Pressure Therapy

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07181447: NIRS for the Diagnosis of Myofascial Pelvic Pain

Study type: OBSERVATIONAL. Phase: .

NCT07161830: Evaluating the Efficacy of OCM™ (Omeza® Complete Matrix) in the Treatment of Diabetic Foot Ulcers

Study type: INTERVENTIONAL. Phase: NA.

NCT07161388: Durvalumab Consolidation After Chemoradiation Therapy for Limited Stage SCLC in China

Study type: OBSERVATIONAL. Phase: .

NCT07111559: Lacunar Stroke hyperAcute Clinical Utilization of Novel Approach Regimens: Rt-PA vs. DAPT Randomised Clinical Trial

Study type: INTERVENTIONAL. Phase: PHASE4.

NCT06822842: Accurate Diagnosis and Grading of Pediatric Solid Tumors Based on Pathological Large Models

Study type: OBSERVATIONAL. Phase: .