Pharmaceutical industry news

Chemotherapy Response Score as a surrogate endpoint for clinical efficacy of neoadjuvant durvalumab and tremelimumab in combination with chemotherapy in newly diagnosed advanced high grade serous ovarian cancer (iPRIME): A randomized, non-comparative phase 2 clinical trial

Integrated clinical, environmental, and healthcare-worker hand surveillance for unit-level infection prevention prioritisation in a Mongolian tertiary hospital: a two-component observational study

Effect of Plasma rich in growth factor with bridge flap in management of Miller’s class I and II gingival recession defects: a comparative clinical study

Sharing Tales That Teach: Protocol for a cohort-embedded randomised trial of caregiver-delivered emotion-focused shared reading in young children

A Phase II Trial of ADI-PEG20 in Combination with Gemcitabine and Docetaxel for the Treatment of Soft Tissue Sarcoma

Clinical case of repeated pregnancy during the menstrual cycle following medication abortion.

Salivary thioredoxin-1 as a non-invasive redox biomarker in oral diseases

Monostotic chronic nonbacterial osteomyelitis/chronic recurrent multifocal osteomyelitis of clavicle mimicking malignant bone tumor: A case report and review of literature

Irritable bowel syndrome and colon cancer: A meta-analysis

Laparoscopic repair of a rare Morgagni hernia: A case report

The Role of Magnetic Resonance Imaging in Sports Injuries: Current Applications and Clinical Importance - A Narrative Review

The therapeutic landscape of cannabidiol: a systematic review of molecular mechanisms, clinical efficacy in oncology and neurology, and regulatory changes

Correction: [18F]FDG PET/CT performs better than CT in determining the bone biopsy site : randomized controlled clinical trial

Predictors of Target Lesion Failure in Patients With In-Stent Restenosis: Insights From the AGENT IDE Trial

Phylogenetic Diversity of Pseudomonas aeruginosa from Diverse Clinical Infections Based on 16S rRNA Gene Sequence Analysis

Nutritional assessment in the era of precision nutrition: from measurement to meaning

Associations Between Antiparietal Cell Antibody Values and Atrophy in a South and Southeast Asian General Population

The Role of Artificial Intelligence Combined With Digital Cholangioscopy for Indeterminant and Malignant Biliary Strictures

Two New Stroke Clinical Trials Evaluate Worth of Combination Therapies

Pharmacogenomic biomarkers in oncology: evidence, clinical utility, and barriers to implementation

Conservative Oxygen for Unresponsive Patients after Cardiac Arrest

Clinical Characteristics of Patients Infected with Bundibugyo Virus, DRC 2026

Combining AI interpretation of cholangiograms and clinical data for postoperative risk stratification after ERCP in cholodocholithiasis

Clinical and radiographic evaluation of natural bovine bone with hyaluronic acid on osseointegration of immediate implants: a randomized clinical study

A suite of engineered mice for interrogating psychedelic drug actions

Clinical outcomes following insertion of second-generation (Aspira®) tunneled indwelling peritoneal catheters to treat malignant ascites

Clinical characteristics etiologies outcomes and complications of total knee arthroplasty in patients aged 18 to 54 years a nationwide inpatient sample analysis

Efficacy and Safety of High-Dose Retatrutide in Adults with Obesity and Type 2 Diabetes: A Systematic Review and Bayesian Meta-Analysis

Undertriage of geriatric trauma patients in the emergency department: A retrospective single-center study

Clinical Research on Microecological Landscape for Infection Risk Stratification in Newly Diagnosed Patients with Hematological Conditions

Effect of Cyanoacrylate Tissue Adhesive on Dehiscence After Absorbable Membrane Fixation in Oral Surgery: A Pilot Randomized Clinical Trial

Molecular diagnostics as the clinical standard in cholangiocarcinoma and hepatocellular carcinoma: a new era of precision oncology

Antimicrobial, antibiofilm, and virulence gene modulatory effects of supercritical CO₂ extracts of Thymbra spicata against clinical MRSA isolates

Genetic characteristics and clinical features of pediatric congenital adrenal hyperplasia in Korea

Renal safety of amikacin compared with ceftriaxone in patients treated for urinary tract infection: an observational cohort study

Improving self-efficacy through nurse navigation in patients during treatment for colorectal cancer: a randomized controlled trial

Modified sutureless flanged intrascleral intraocular lens fixation in pediatric patients: clinical outcomes over 2 years of follow-up

Efficacy and safety of vunakizumab in patients with moderate-to-severe plaque psoriasis with a high drug interruption rate during the COVID-19 pandemic: a post hoc analysis from a single center of a phase III trial

Association and discriminative value of serum inflammatory biomarkers for sarcopenic obesity: A retrospective cross‐sectional study

<scp> <i>UMOD</i> </scp> Genotype and Clinical Outcomes in Heart Failure Patients Treated with Loop Diuretics: A <scp>UK</scp> Biobank Pharmacogenetic Cohort Study

NCT07751016: A Clinical Study of KH001 for Pulp Preservation and Safety in Deep Dentin Caries

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07750990: An Extension Study of S-606001 in Participants With Late-onset Pompe Disease (LOPD)

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07750964: Intravascular Lithotripsy Versus Rotational Atherectomy for Severe Coronary Artery Calcification: A Prospective, Multicenter, Non-inferiority Randomized Controlled Trial

Study type: INTERVENTIONAL. Phase: NA.

NCT07750951: Single-arm, Phase II Clinical Study Evaluating the Safety and Efficacy of Sintilimab Combined With IBI-310 and Chemotherapy as Neoadjuvant Therapy for Locally Advanced Rectal Cancer

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07750522: Correlation Between MRI Findings and Clinical Improvement Following TMJ Injection With Hyaluronic Acid and Platelet-Rich Plasma

Study type: INTERVENTIONAL. Phase: NA.

NCT07750483: Efficacy of Intra-Articular Hyaluronic Acid Combination Injections for Temporomandibular Joint Internal Derangement: A Clinical and MRI Based Randomized Trial

Study type: INTERVENTIONAL. Phase: NA.

NCT07750080: The Effect of Multimodal Approach of Electrotherapy Versus Shock Wave Therapy in Menopausal Women With Tennis Elbow.

Study type: INTERVENTIONAL. Phase: NA.

NCT07749859: SHR-1701 Plus Apatinib for Second-Line Treatment in Targeted-Immune Pretreated Advanced Hepatocellular Carcinoma

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07749443: Construction and Empirical Study of Indirect Intervention Model for Protective Medical Lung Cancer Patients Based on Family System Theory

Study type: INTERVENTIONAL. Phase: NA.

NCT07749365: Hypofractionated Radiotherapy Plus GM-CSF, Pomalidomide and Glofitamab for Newly Diagnosed PCNS-DLBCL

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07749326: Conventional Versus Stomach-Partitioning Gastrojejunostomy for Malignant Gastric Outlet Obstruction in Stage IV Gastric Cancer (KLASS 16)

Study type: INTERVENTIONAL. Phase: NA.

NCT07749118: HB05P on Muscle Health

Study type: INTERVENTIONAL. Phase: NA.

NCT07749014: Timing of Empagliflozin in Primary PCI: Pre-Reperfusion Versus Post-Reperfusion Versus Placebo in South Asian STEMI Patients

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07736950: A Study Comparing a New Drug (Surovatamig) With Standard Radiotherapy With or Without Rituximab in Adults With Limited Stage Nodal Follicular Lymphoma

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07673250: Personalized Ventilator Settings for Patients on ECMO

Study type: INTERVENTIONAL. Phase: NA.

NCT07670130: Venetoclax TDM in Newly Diagnosed AML: Exposure-Response and Prognosis

Study type: OBSERVATIONAL. Phase: .

NCT07659795: A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Colorectal Cancer

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07512271: Generative AI Patient Education Module for Breast Oncology

Study type: INTERVENTIONAL. Phase: NA.

NCT07504744: Klotho Gene, Red Complex Bacteria and Periodontal Viruses in Patients With and Without Periodontitis and Acute Coronary Syndrome

Study type: OBSERVATIONAL. Phase: .

NCT07444619: A Phase I Study of Pazopanib in Combination With Trabectedin, Ipilimumab and Nivolumab (TraPIN) in Pediatric and Young Adult Patients With Recurrent Soft Tissue Sarcomas

Study type: INTERVENTIONAL. Phase: PHASE1.