Pharmaceutical industry news

Erratum to Clonal expansion of alveolar fibroblast progeny drives pulmonary fibrosis in mouse models

Corrigendum to Elevated microRNA-187 causes cardiac endothelial dysplasia to promote congenital heart disease through inhibition of NIPBL

Going to the source: pancreatic lymph nodes maintain stem-like CD8+ T cells in human type 1 diabetes

Response by Zhao et al to Letter Regarding Article, “Dapagliflozin to Reduce Early Recurrence After Catheter Ablation for Atrial Fibrillation: The DARE-AF Randomized Clinical Trial”

Letter by Xu et al Regarding Article, “Dapagliflozin to Reduce Early Recurrence After Catheter Ablation for Atrial Fibrillation: The DARE-AF Randomized Clinical Trial”

Table S5 from CRB-701: A Second-generation Nectin-4–Targeted Antibody–Drug Conjugate with Optimized Stability and Pharmacokinetics for the Treatment of Solid Tumors

Table S9 from CRB-701: A Second-generation Nectin-4–Targeted Antibody–Drug Conjugate with Optimized Stability and Pharmacokinetics for the Treatment of Solid Tumors

Data from Molecular and Clinical Determinants of Targeted Therapy Treatment in Biliary Tract Cancer

Data from Investigational Clinical Trial Agents versus Conventional Second Salvage Therapies in Patients with Relapsed/Refractory Acute Myeloid Leukemia

Supplementary Figure S1 from Molecular and Clinical Determinants of Targeted Therapy Treatment in Biliary Tract Cancer

Supplementary Figure S2 from The First-in-Human ENCIT01 Trial Comparing Second- versus Third-Generation L1CAM-specific CAR T Cells in Patients with Primary Refractory or Relapsed Neuroblastoma

Supplementary Table S1 from Clinical Validation of a Multiplex Urine Biomarker Assay for Surveillance of Recurrent Bladder Cancer

EGFR Mutation Subtype and Risk of Brain Metastases From Non–Small Cell Lung Cancer in the Osimertinib Era

Music-based interventions in adult stroke rehabilitation: a narrative review of clinical applications, proposed mechanisms, and implementation

“The Eyes Reveal Systemic Secrets”—diverse systemic associations in branch retinal vein occlusion: a case series highlighting pathogenic mechanisms and clinical insights

An Integrated Approach Combining Receptor-Based Ensemble Screening and <i>In Vivo</i> Phenotypic Assessment Improves Drug-Induced Liver Injury Prediction

Integrated analysis of aluminum oxide nanoparticle effects on Camelina sativa performance and molecular signaling

Antimicrobial stewardship in acute exacerbations of COPD: a qualitative study of hospital pharmacists’ perspectives

Preclinical Pharmacokinetic and Pharmacological Profiling of B339, a Novel SARM1 Inhibitor for the Treatment of Vincristine-induced Peripheral Neuropathy

A Flexible-Horizon Clinical Decision Support Model for Dementia Early Detection and Risk Prediction in Secondary Care: A Responsible AI Approach

Distinct risk profiles of heart failure and non-heart failure major adverse cardiovascular events among patients with early breast cancer: a competing-risk analysis

Meteorological factors and primary care consultation patterns in rheumatoid arthritis and axial spondyloarthritis: a 14-year population-based time-series study

Effectiveness of symptom map-based education in the management of premenstrual syndrome: a randomized controlled trial

Intraocular pressure and optical coherence tomography parameters in pediatric hydrocephalus: a comparative analysis of patients with and without shunts versus healthy controls

Transabdominal lumbar approach (TALA) versus retroperitoneal approach for robot-assisted renal surgery: a prospective randomised controlled trial

Decoding Nano-Bio Interactions: Gene Regulatory Networks in Advanced Drug Loading

µ2N‐Bots: A Dual‐Responsive Cross‐Scale Synergistic Strategy for Hierarchical Drug Delivery

Guided bone regeneration using titanium mesh and xenogeneic graft alone: Histologic findings and 7‐year follow‐up

Prescription Drug Use Among US Adults

High-Dose Intravenous Vitamin C and Mortality and Organ Dysfunction in Severe Burn Injury

NCT07821411: A Real-World Study of Ofatumumab in Multiple Sclerosis Patients in Germany and Japan

Study type: OBSERVATIONAL. Phase: .

NCT07821372: A Plant-Based Diet in the Treatment of Coronary Microvascular Dysfunction

Study type: INTERVENTIONAL. Phase: NA.

NCT07820839: Digital Stimulation and Anxiety and Sleep Quality in Intensive Care Unit Patients

Study type: INTERVENTIONAL. Phase: NA.

NCT07820436: Interactive Robot-Guided Exercise Program for Cancer-Related Fatigue

Study type: INTERVENTIONAL. Phase: NA.

NCT07820345: Development and Evaluation of Low-Cost Non-Animal Biological Simulation Models for Undergraduate Surgical Training in Trauma Tissue Reconstruction

Study type: INTERVENTIONAL. Phase: NA.

NCT07819812: Thiotepa-Based Conditioning for Haploidentical HSCT in Older Patients With Severe Aplastic Anemia

Study type: INTERVENTIONAL. Phase: NA.

NCT07819669: Video-Assisted Thoracoscopic Surgery Combined With Radiofrequency Ablation Versus VATS Alone for Multiple Primary Lung Cancer

Study type: INTERVENTIONAL. Phase: NA.

NCT07819487: A Community Health Worker Service to Address Acute Care Utilization Among Young and Middle-Aged Men and Women Receiving Dialysis in High-Poverty Communities

Study type: OBSERVATIONAL. Phase: .

NCT07819474: Optimizing Tumor-Infiltrating Lymphocyte (TIL) Harvest Site and Patient Selection With CD8-PET Imaging in Patients With

Study type: INTERVENTIONAL. Phase: NA.

NCT07818590: The Effect of Nanoparticle Coating of Orthodontic Brackets on The Rate of Canine Retraction: A Randomized Clinical Trial

Study type: INTERVENTIONAL. Phase: NA.

NCT07816380: A Phase III Study to Evaluate the Efficacy and Safety of JYP0322 in Previously Untreated ROS1-Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07811219: RESP-FIT: A Respiratory Muscle Strength Training Intervention for COPD

Study type: INTERVENTIONAL. Phase: NA.

NCT07794072: Digital Patient Engagement in Technology-Supported Neurorehabilitation

Study type: OBSERVATIONAL. Phase: .

NCT07771439: A Study to Investigate the Efficacy and Safety of Belumosudil Compared With Best Available Therapy in Participants Aged 12 Years or Older With Chronic Graft-versus-host Disease

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07758543: Combined Effects of Proprioceptive Neuromuscular Facilitation (PNF) and Neural Mobilization on Improving Facial Symmetry in Patients With Bells Palsy

Study type: INTERVENTIONAL. Phase: NA.

NCT07748403: A Study of the Safety and Efficacy of Prime Editing (PM577) in Participants With Wilson Disease (WD)

Study type: INTERVENTIONAL. Phase: PHASE1, PHASE2.

NCT07687160: SPIRO-First: A Pragmatic Primary Care-Embedded Pilot Trial of Renin-Guided First-Line Antihypertensive Therapy

Study type: INTERVENTIONAL. Phase: PHASE4.

NCT07686380: IL-15 Superagonist With or Without Vaccine in Biochemically Recurrent Prostate Cancer After Previous Stereotactic Body Radiation Therapy

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07605130: Efficacy and Safety Study of Digital Cognitive Training and PCSK9 Inhibitor-Enhanced Lipid-lowering Strategy in Patients With Intracranial Atherosclerotic Stenosis: A 2x2 Factorial, Randomized, Parallel-Group, Multicenter Trial

Study type: INTERVENTIONAL. Phase: PHASE4.

NCT07573462: A Study to Learn About the Safety of an Expanded Pneumococcal Vaccine in Healthy Infants

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07548034: Ultrasound-guided Needle Percutaneous Electrolysis With Therapeutic Exercise in Femoroacetabular Impingement Syndrome

Study type: INTERVENTIONAL. Phase: NA.

NCT07455513: A Novel Tobacco Cessation Resource for Smokers With a Diagnosed or Suspected Thoracic Cancer

Study type: INTERVENTIONAL. Phase: NA.

NCT07424677: Study of Saroglitazar Magnesium for PBC Patients With Incomplete Response or Intolerant to UDCA Therapy

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07399730: Ravulizumab Outcomes in Polish Patients With aHUS

Study type: OBSERVATIONAL. Phase: .

NCT07384195: A Study to Assess Efficacy and Safety of N-Acetyl-GED-0507-34-LEVO Gel 5%, in Patients With Acne Vulgaris (GEDACNE-1)

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07384052: Safety and Feasibility of Intranasal Insulin in Patients With Spinal Cord Injury

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07223190: A Study Evaluating Subcutaneous Versus Intravenous Blinatumomab in Newly Diagnosed Adults With B-cell Precursor Acute Lymphoblastic Leukaemia

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07217704: Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Gastric or Esophageal Cancer.

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07217223: Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression: A Home-Based Feasibility and Safety Study

Study type: INTERVENTIONAL. Phase: NA.

NCT07186673: Hall Technique vs Conventional Crown Restoration in Permanent Molars: Split-Mouth Trial in Children

Study type: INTERVENTIONAL. Phase: NA.