Pharmaceutical industry news

Effect of cryoanaesthesia on pain during intraoral anaesthetic puncture in children: a randomised controlled non-inferiority trial

Immunomodulatory effects of glycyrrhizin and glucomannan on cytokine gene expression in human PBMCs: implications for vaccine adjuvant development

Biomimetic Nanocarriers Based on Cell Membranes for Precision Drug Delivery: Advances, Applications, and Translational Challenges

Development and Evaluation of a Lapatinib-Loaded Lipomer Formulation for Pulmonary Drug Delivery

RP-HPLC Method for Simultaneous Quantification of Captopril and Hydrochlorothiazide in a Bilayer Multi-unit Pellet System

Epigallocatechin Gallate (EGCG)-Loaded Hydrogel for Topical Chronic Non-Communicable Skin Inflammation

Prevention of lymphedema after extended pelvic lymphadenectomy using diosmin, bromelain, melilotus, and hesperidin: results from a prospective randomized study (PRELYNE trial)

Clinical Characteristics, Diagnosis, and Treatment of Central Nervous System Candidiasis: A Systematic Review of 418 Cases

Physician views on ethically challenging clinical scenarios: a society for reproductive endocrinology and infertility member survey

Retraction Note: Integrative multi-omics profiling for early diagnosis, stratification and personalized management of chronic kidney disease: a new paradigm

Age-stratified associations of oral hygiene care with dental caries and periodontitis: cross-sectional analysis of seventh Korea national health and nutrition examination survey

Intraoperative nociceptive comparisons between sedation with different opioids or local blocks in police working dogs: a retrospective analysis

Cancer-related cognitive impairment in adult cancer survivors: a clinical practice review for healthcare providers

A retrospective study of the clinical efficacy of arthroscopic double-row and single-row suture-bridge techniques for rotator cuff tears

In vivo analysis of Schlemm’s canal axial dimensions in children with juvenile idiopathic arthritis–associated uveitis

Quantification of vitreous VEGF-A121 and VEGF-A165 using an isoform-specific ELISA in proliferative diabetic retinopathy

Tranexamic acid after aneurysmal subarachnoid hemorrhage is associated with worse outcome in males: post hoc analysis of the ULTRA trial

Comparison of clinical outcomes of triple-strand braid vs conventional quad-strand hamstring grafts in anterior cruciate ligament reconstruction

Correction to “Pre‐treatment Serum Albumin Concentration Predicts Clinical Benefit of Long‐Term Albumin in Patients With Cirrhosis and Ascites”

The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity

Development and Validation of an HPLC–MS/MS Method for the Determination of Benzodiazepines in Hair. Comparison of Two Different Extractions and Applications on Real Samples

NCT07775014: Percutaneous Cryoablation for the Treatment of Breast Cancer

Study type: INTERVENTIONAL. Phase: NA.

NCT07774936: Fetal Health Locus of Control, Maternal Anxiety, and Cardiotocography in High-Risk Pregnancies

Study type: OBSERVATIONAL. Phase: .

NCT07774091: Clinical Outcomes After Treatment of Distal Humerus Fractures With the LORRAINE 2.5/3.5 mm Distal Humerus System

Study type: OBSERVATIONAL. Phase: .

NCT07773961: School-based Prevention of Teacher Violence Against Children: A Cluster-randomized Controlled Trial in Zambia

Study type: INTERVENTIONAL. Phase: NA.

NCT07773012: Efficacy of Bifidobacterium Animalis Subsp. Lactis in the Treatment of Indirect Hyperbilirubinemia in Term Neonates

Study type: INTERVENTIONAL. Phase: NA.

NCT07772895: Pemefolacianine for IMI of Lung Cancer

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07772661: Comaparative Effects of Bowen Technqiue With and Withour Extracorporeal Shock Wave in Patientys With Deep Gliteal Pain Syndrome.

Study type: INTERVENTIONAL. Phase: NA.

NCT07772570: Multimodal Biomarkers in Coronary Artery Disease Pathogenesis: The Oxford Acute Myocardial Infarction Study (OXAMI Study)

Study type: OBSERVATIONAL. Phase: .

NCT07772466: Atherosclerosis in Early Rheumatoid Arthritis Patients Using Atherogenic Index of the Plasma and Carotid Intima Media Thickness

Study type: OBSERVATIONAL. Phase: .

NCT07770958: Circadian Disruption And Cardiovascular Risk In Young Adults With Hypertension

Study type: OBSERVATIONAL. Phase: .

NCT07762703: Combination Immunotherapy Treatment for Locally Advanced Unresectable or Metastatic, PD-L1 Negative (CPS<10), gBRCA Negative, Triple Negative Breast Cancer Including BreakVax ImmunoTreatment (Designed and Manufactured Per Patient), Chemotherapy and Anti PD-1 Therapy

Study type: INTERVENTIONAL. Phase: PHASE1, PHASE2.

NCT07726888: Efficacy and Safety of Guselkumab in Patients With Moderate-to-Severe Ulcerative Colitis

Study type: OBSERVATIONAL. Phase: .

NCT07588698: Epcoritamab in Combination With R-CHOP for Patients With Aggressive Non-Hodgkin Lymphoma

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07584356: A Study Comparing Shoulder Replacement Techniques For Patients With Shoulder Arthritis And An Intact Rotator Cuff

Study type: INTERVENTIONAL. Phase: NA.

NCT07504458: Pivotal Open-label Phase 3 Clinical Study of QTX-2101 in Adult Patients With Acute Promyelocytic Leukemia

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07499674: Evaluation of the Safety and Efficacy of Abenacianine (VGT-309) to Identify Cancer in Subjects Undergoing Surgery for Cancer in the Lung

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07493304: Treatment and Secondary Prevention of Venous Thromboembolism (VTE) in Adult Participants With Solid and Hematologic Cancers

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07474558: SCALp Cooling for pReventing aLopecia With nEw anTibody-drug Conjugates

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07293143: Glycemic Effects of Meals - Repeatability Trial With Continuous Glucose Monitoring

Study type: INTERVENTIONAL. Phase: NA.

NCT07224633: A Clinical In-Use Evaluation to Assess the Tolerability and Efficacy of a Moisturizer on Acne Prone Skin

Study type: INTERVENTIONAL. Phase: NA.

NCT07203053: A Trial of Tarlatamab in Patients With Pretreated Extensive-stage Small Cell Lung Cancer (ES-SCLC) and ECOG PS 2

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07115043: A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors

Study type: INTERVENTIONAL. Phase: PHASE1, PHASE2.

NCT07042295: Treatment With Amivantamab and Hyaluronidase or Cetuximab for Advanced Skin Cancer in People With a Weakened Immune System

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07029386: Effects of Transcranial Electrical Stimulation on Cognitive Impairment in CNS Inflammatory Demyelinating Diseases

Study type: INTERVENTIONAL. Phase: NA.

NCT07005362: Fitbit and AI Chatbot in Sedentary Primary Care Patients With T2D

Study type: OBSERVATIONAL. Phase: .

NCT06860529: Serplulimab Combined With Chemotherapy for Early-stage HR+/HER2- Breast Cancer

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT06788678: A Randomized Controlled Trial of a Web-Based Moral Elevation Intervention for Veterans With PTSD

Study type: INTERVENTIONAL. Phase: NA.

NCT06683352: A Study to Learn About Flu and COVID-19 Vaccine Responses in Healthy People

Study type: INTERVENTIONAL. Phase: PHASE1, PHASE2.

NCT06597734: A Phase 2 Study Evaluating Olutasidenib in Combination With Hypomethylating Agents in Patients With IDH1-mutated Higher-risk Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, or Advanced Myeloproliferative Neoplasm

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT06465810: Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis

Study type: OBSERVATIONAL. Phase: .

NCT06092346: A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders

Study type: OBSERVATIONAL. Phase: .

NCT06042478: Phase 3b Study to Assess the Efficacy, Safety, and Tolerability of Remibrutinib in Comparison to Placebo, With Omalizumab as Active Control, in Adult CSU Patients, Followed by an Open-label 52-week Optional Extension.

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT05790239: MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT05527652: Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in Hypotonia

Study type: INTERVENTIONAL. Phase: NA.

NCT05424783: MRI And GPS Informing Choices for Prostate Cancer Treatment (MAGIC)

Study type: OBSERVATIONAL. Phase: .

NCT05377255: Pharmacokinetics (PK) and Safety of Multiple Doses of Intranasal Naloxone in Healthy Adults

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT04803084: Multiparametric MRI as a Non-Invasive Biomarker of the Tumor Microenviroment

Study type: OBSERVATIONAL. Phase: .

NCT04339777: Allogeneic Hematopoietic Stem Cell Transplant for Patients With Inborn Errors of Immunity

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT03740165: Study of Chemotherapy With Pembrolizumab (MK-3475) Followed by Maintenance With Olaparib (MK-7339) for the First-Line Treatment of Women With BRCA Non-mutated Advanced Epithelial Ovarian Cancer (EOC) (MK-7339-001/KEYLYNK-001/ENGOT-ov43/GOG-3036)

Study type: INTERVENTIONAL. Phase: PHASE3.