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Fresh coverage across pharma, biotech, medtech, research, approvals, and market-moving developments.

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🌍Researchdoi.org

Impact of vascular and cardiac parameters on quality of life in patients undergoing catheter ablation for atrial fibrillation

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🌍Researchdoi.org

Old drug with new application: spironolactone suppresses Panx 1-mediated Ca2+ influx to attenuate inflammation-driven neutral lipid accumulation in early atherosclerosis

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🌍Researchdoi.org

Craniofacial Morphology and Dental Age Assessment in Pediatric Craniosynostosis: A Comparative Cross‐Sectional Study

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🌍Researchdoi.org

Environmental Burdens of Long‐Term Cadaver Pool Storage Solutions: A Screening Cradle‐to‐Gate Life Cycle Assessment of Three Formulations

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🌍Researchdoi.org

Practical Computational Exploration of Chemical Reaction Space: Assessing the Chemical Stability of Active Pharmaceutical Ingredients Under Acidic Conditions

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🌍Researchdoi.org

Neonatal Ventilation Training Using a Low-Cost, High-Fidelity Simulator in a Low-Resource Setting

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🇺🇸Researchclinicaltrials.gov

NCT07819110: Radicle HealthTM VIP: A Study Assessing the Impact of Health and Wellness Products on Metabolic Health and Related Health Outcomes

Study type: INTERVENTIONAL. Phase: NA.

ClinicalTrials.govOriginal source
🇺🇸Researchclinicaltrials.gov

NCT07818395: Spatial Multi-Omics of Perineural Invasion Microenvironment and Prognosis in Prostate Cancer

Study type: OBSERVATIONAL. Phase: .

ClinicalTrials.govOriginal source
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NCT07818174: Graded Motor Imagery Effects on Body Perception Disturbance in Complex Regional Pain Syndrome : a Randomised Controlled Trial

Study type: INTERVENTIONAL. Phase: NA.

ClinicalTrials.govOriginal source
🇺🇸Researchclinicaltrials.gov

NCT07817186: Clinical Trial of a MEK Inhibitor for RASopathy-Associated Severe Infantile Hypertrophic Cardiomyopathy: Baby MERIT

Study type: INTERVENTIONAL. Phase: PHASE3.

ClinicalTrials.govOriginal source
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NCT07817004: QLM2010 Comparative Pharmacokinetic Study With 2-Minute Intravenous Administration

Study type: INTERVENTIONAL. Phase: PHASE1.

ClinicalTrials.govOriginal source
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NCT07816731: EFFECT OF FACE-TO-FACE AND VIRTUAL REALITY-BASED SALUTOGENESIS NURSING CARE IN PATIENTS WITH DEMENTIA

Study type: INTERVENTIONAL. Phase: NA.

ClinicalTrials.govOriginal source
🇺🇸Researchclinicaltrials.gov

NCT07816666: Torvutatug Samrotecan With or Without Bevacizumab as Maintenance Treatment of Platinum-sensitive Relapsed Epithelial Ovarian Cancer

Study type: INTERVENTIONAL. Phase: PHASE3.

ClinicalTrials.govOriginal source
🇺🇸Researchclinicaltrials.gov

NCT07815678: First-in-human Study of the Safety, Tolerability, Pharmacokinetics, and Food Effect of ACCG-2671

Study type: INTERVENTIONAL. Phase: PHASE1, PHASE2.

ClinicalTrials.govOriginal source
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NCT07810478: Criteria-Based Rehabilitation After Tibial Fracture Fixation: A Randomized Controlled Trial

Study type: INTERVENTIONAL. Phase: NA.

ClinicalTrials.govOriginal source
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NCT07739459: Study of Zanubrutinib in Older Patients With Previously Untreated Chronic Lymphocytic Leukemia (CLL)

Study type: INTERVENTIONAL. Phase: PHASE2.

ClinicalTrials.govOriginal source
🇺🇸Researchclinicaltrials.gov

NCT07673913: Relationship of Peripheral Inflammatory and Neuroprotective Biomarkers With Response to Intermittent Theta Burst Stimulation in Treatment-Resistant Depression

Study type: INTERVENTIONAL. Phase: NA.

ClinicalTrials.govOriginal source
🇺🇸Researchclinicaltrials.gov

NCT07554339: A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell Lung Cancer (MK-1084-015/KANDLELIT-015)

Study type: INTERVENTIONAL. Phase: PHASE3.

ClinicalTrials.govOriginal source
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NCT07516184: Explore the Diagnostic Value of Bronchodilation Test With Portable Oscillometry in Asthma Diagnosis

Study type: INTERVENTIONAL. Phase: NA.

ClinicalTrials.govOriginal source
🇺🇸Researchclinicaltrials.gov

NCT07513389: Omission of Postoperative Radiation in HPV-Associated Oropharyngeal Cancer Using ctHPVDNA Surveillance (OPERATION)

Study type: INTERVENTIONAL. Phase: PHASE2.

ClinicalTrials.govOriginal source
🇺🇸Researchclinicaltrials.gov

NCT07465757: A Study of Alisertib and Paclitaxel in Patients With Small Cell Lung Cancer (SCLC)

Study type: INTERVENTIONAL. Phase: PHASE2.

ClinicalTrials.govOriginal source
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NCT07451899: TB Type and Spirometry Result vs. Functional Capacity Based on 6MWT in People With Post-TB Lung Disease

Study type: OBSERVATIONAL. Phase: .

ClinicalTrials.govOriginal source
🇺🇸Researchclinicaltrials.gov

NCT07218146: A Study of ZL-1310 Versus Investigator's Choice of Therapy in Participants With Relapsed Small Cell Lung Cancer (DLLEVATE)

Study type: INTERVENTIONAL. Phase: PHASE3.

ClinicalTrials.govOriginal source
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NCT07098351: Efficacy and Safety of Nalfurafine Hydrochloride ODT for Moderate-to-Severe Pruritus in Patients on Peritoneal Dialysis

Study type: INTERVENTIONAL. Phase: NA.

ClinicalTrials.govOriginal source
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NCT06991738: 177Lu-DOTA-EB-TATE in Adult Patients With Metastatic, Radioactive Iodine Non-Responsive Oncocytic (Hurthle-Cell) Thyroid Cancer

Study type: INTERVENTIONAL. Phase: PHASE1, PHASE2.

ClinicalTrials.govOriginal source
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NCT06899308: Health Surveillance at Constructor University Bremen (CUB)

Study type: OBSERVATIONAL. Phase: .

ClinicalTrials.govOriginal source
🇺🇸Researchclinicaltrials.gov

NCT06860698: The Impact of Chronic E-Cigarette Usage on Microvascular Health

Study type: OBSERVATIONAL. Phase: .

ClinicalTrials.govOriginal source
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NCT06820463: A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer

Study type: INTERVENTIONAL. Phase: PHASE2.

ClinicalTrials.govOriginal source
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NCT06797661: Insights Into the Pathophysiology of Neurovascular Uncoupling in Patients With Brain Lesions.

Study type: INTERVENTIONAL. Phase: NA.

ClinicalTrials.govOriginal source
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NCT06794125: An Evaluation of Dose-escalation for Intrathoracic Tumours

Study type: INTERVENTIONAL. Phase: NA.

ClinicalTrials.govOriginal source
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NCT06789198: Peptide Vaccine for Fibrolamellar Hepatocellular Carcinoma Patients and Other Tumor Entities Carrying the Driver Fusion DNAJB1-PRKACA

Study type: INTERVENTIONAL. Phase: PHASE1.

ClinicalTrials.govOriginal source
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NCT06595940: Genetic Analysis of Uncommon Disease Presentations in Non-US Populations

Study type: OBSERVATIONAL. Phase: .

ClinicalTrials.govOriginal source
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NCT06590051: AMG 335 Expanded Access Program for IgG4-Related Disease

Study type: EXPANDED_ACCESS. Phase: .

ClinicalTrials.govOriginal source
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NCT06549153: ACT-Together (Acting on Cancer Testing-Together)

Study type: INTERVENTIONAL. Phase: NA.

ClinicalTrials.govOriginal source
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NCT06282575: Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer

Study type: INTERVENTIONAL. Phase: PHASE3.

ClinicalTrials.govOriginal source
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NCT06263283: Impact of an Educational Physiotherapy-Yoga Intervention on Perceived Stress in Women Treated With Brachytherapy for Cervical Cancer

Study type: INTERVENTIONAL. Phase: NA.

ClinicalTrials.govOriginal source
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NCT06065748: A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)

Study type: INTERVENTIONAL. Phase: PHASE3.

ClinicalTrials.govOriginal source
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NCT05827081: Phase IIIb Study of Ribociclib + ET in Early Breast Cancer

Study type: INTERVENTIONAL. Phase: PHASE3.

ClinicalTrials.govOriginal source
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NCT05642195: Evaluation of a Cancer Lysate Vaccine and Montanide (Registered Trademark) ISA-51 VG With or Without the IL-15 Super-Agonist N-803 as Adjuvant Therapy for PD-L1 Negative Non-Small Cell Lung Cancer

Study type: INTERVENTIONAL. Phase: PHASE1, PHASE2.

ClinicalTrials.govOriginal source
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NCT05482516: Evaluating Novel Therapies in ctDNA Positive GI Cancers

Study type: INTERVENTIONAL. Phase: PHASE3.

ClinicalTrials.govOriginal source
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NCT05172245: Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer

Study type: INTERVENTIONAL. Phase: PHASE1.

ClinicalTrials.govOriginal source
🇺🇸Researchclinicaltrials.gov

NCT05041387: Data Collection of Standard Care of Patients in the EMG Section

Study type: OBSERVATIONAL. Phase: .

ClinicalTrials.govOriginal source
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NCT04751409: Evaluating the Impact of Limited Compared With Intense Post-Operative Surveillance on Patient-Reported Outcomes in Patients With Stage II-III Soft Tissue Sarcoma of the Trunk and Extremities

Study type: INTERVENTIONAL. Phase: PHASE2.

ClinicalTrials.govOriginal source
🇺🇸Researchclinicaltrials.gov

NCT04708067: Hypofractionated Radiation Therapy and Bintrafusp Alfa for the Treatment of Advanced Intrahepatic Cholangiocarcinoma

Study type: INTERVENTIONAL. Phase: PHASE1.

ClinicalTrials.govOriginal source
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NCT04543617: A Study of Atezolizumab With or Without Tiragolumab in Participants With Unresectable Esophageal Squamous Cell Carcinoma Whose Cancers Have Not Progressed Following Definitive Concurrent Chemoradiotherapy

Study type: INTERVENTIONAL. Phase: PHASE3.

ClinicalTrials.govOriginal source
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NCT04449549: Rapid Analysis and Response Evaluation of Combination Anti-Neoplastic Agents in Rare Tumors (RARE CANCER) Trial: RARE 1 Nilotinib and Paclitaxel

Study type: INTERVENTIONAL. Phase: PHASE2.

ClinicalTrials.govOriginal source
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NCT04221750: Diet and Exercise Plus Metformin to Treat Frailty in Obese Seniors

Study type: INTERVENTIONAL. Phase: PHASE3.

ClinicalTrials.govOriginal source
🇺🇸Researchclinicaltrials.gov

NCT04115631: A Comparison of Three Chemotherapy Regimens for the Treatment of Patients With Newly Diagnosed Mantle Cell Lymphoma

Study type: INTERVENTIONAL. Phase: PHASE2.

ClinicalTrials.govOriginal source
🇺🇸Researchclinicaltrials.gov

NCT04021329: Efficacy of Eye Movement Desensitization & Reprocessing Versus Cognitive Behavioral Therapy in Post-Traumatic Stress and Depressive Disorders

Study type: INTERVENTIONAL. Phase: NA.

ClinicalTrials.govOriginal source
🇺🇸Researchclinicaltrials.gov

NCT03683433: Enasidenib and Azacitidine in Treating Patients With Recurrent or Refractory Acute Myeloid Leukemia and IDH2 Gene Mutation

Study type: INTERVENTIONAL. Phase: PHASE2.

ClinicalTrials.govOriginal source
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NCT03533582: Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery

Study type: INTERVENTIONAL. Phase: PHASE3.

ClinicalTrials.govOriginal source
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NCT03214562: Venetoclax With Combination Chemotherapy in Treating Patients With Newly Diagnosed or Relapsed or Refractory Acute Myeloid Leukemia

Study type: INTERVENTIONAL. Phase: PHASE1, PHASE2.

ClinicalTrials.govOriginal source
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NCT03137511: Optimizing Access to Care Through New Technologies: a Randomized Study Evaluating the Impact of Telephone Contact and the Sending by the General Practitioner of Suspicious Lesions Melanoma Photographs Taken With a Smartphone, on the Time Limit to the Consultation With a Dermatologist

Study type: INTERVENTIONAL. Phase: NA.

ClinicalTrials.govOriginal source
🇺🇸Researchclinicaltrials.gov

NCT02698579: Long-term Follow-up of Participants With Cerebral Adrenoleukodystrophy Who Were Treated With Lenti-D Drug Product

Study type: OBSERVATIONAL. Phase: .

ClinicalTrials.govOriginal source
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NCT01660984: Natural History Study of Children and Adults With Medullary Thyroid Cancer

Study type: OBSERVATIONAL. Phase: .

ClinicalTrials.govOriginal source
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NCT01630278: Early Ibuprofen Treatment of Patent Ductus Arteriosus (PDA) in Premature Infants (TRIOCAPI)

Study type: INTERVENTIONAL. Phase: PHASE3.

ClinicalTrials.govOriginal source
🇺🇸Researchclinicaltrials.gov

NCT01386034: Effects of Oral Citrulline on Protein Metabolism in Patients With Intestinal Failure (Citrugrêle 2)

Study type: INTERVENTIONAL. Phase: PHASE3.

ClinicalTrials.govOriginal source
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NCT01061255: Stress and Clinical Reasoning in Medical Students

Study type: INTERVENTIONAL. Phase: NA.

ClinicalTrials.govOriginal source
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NCT00841724: Study of a Reduced-toxicity "Submyeloablative" Conditioning Regimen Prior to Allogeneic Stem Cell Transplantation in Patients With Hematological Malignancies

Study type: INTERVENTIONAL. Phase: PHASE2.

ClinicalTrials.govOriginal source
🇺🇸Researchclinicaltrials.gov

NCT00791635: Longitudinal Evaluation of Women Undergoing Pelvic Surgery for the Treatment of Gynecologic Cancer

Study type: OBSERVATIONAL. Phase: .

ClinicalTrials.govOriginal source