Pharmaceutical industry news

Clinical Impact of Interlesion Distance on Acute Pulmonary Vein Isolation Success in Patients With Paroxysmal Atrial Fibrillation

Happy Homework 2.0: effects on 24-hour movement behaviours in children—findings from a pilot cluster randomised controlled trial

Parent-delivered early language intervention for children with Down syndrome: a feasibility randomized controlled trial

Preclinical evidence for supra-clinical acute kidney injury: current biomarkers are not enough

Study protocol: efficacy and safety of Limosilactobacillus fermentum WIS32 as an adjunctive treatment for major depressive disorder—a randomized, double-blind, placebo-controlled trial

Safety and efficacy of individualized target transcranial magnetic stimulation for major depressive disorder based on DLPFC-pgACC functional connectivity: a randomized, sham-controlled clinical trial

Secondary prevention of cancer therapy-induced thrombocytopenia with hetrombopag in breast cancer: a multicenter, randomized, exploratory phase II trial

Efficacy and mechanisms of device-monitored aerobic exercise for depression treatment and cognitive function improvement (DAECD trail): protocol for a randomized controlled trial

Effects of different sites or areas of preoperative lateral compartment bone marrow edema on the midterm clinical outcomes of medial unicompartmental knee arthroplasty

NKAIN1 predicts poor prognosis and associated with drug resistance and immune infiltration in prostate adenocarcinoma

Clinical characteristics and prognostic factors in pediatric atypical teratoid/rhabdoid tumor: a single-center retrospective study

No specific molecular profile (NSMP) endometrial cancer: from residual category to clinical decision driver

Genome sequences of clinical EHEC isolates from Germany’s large 2025 O45:H2 outbreak, revealing multidrug resistance and unusual strain diversity

Mini‐Open Versus Open Transforaminal Lumbar Interbody Fusion in Patients Aged ≥ 75 Years: Perioperative Surgical Burden and Clinical Outcomes

Letter to Editor in Response to “GLP‐1 RA Plus SGLT2i Versus Monotherapy in MASLD and Type 2 Diabetes: Three Pairwise Target Trial Emulations”

Uncovering the Genetic Landscape of Pediatric Hearing Loss Along the Texas–Mexico Border

Long‐term results of brentuximab vedotin and bendamustine for first‐line treatment of Hodgkin lymphoma in the elderly ( <scp>HALO</scp> trial)

Genomic diversity of Pseudomonas aeruginosa causing bacteremic pneumonia in an intensive care unit, with emergence of an OXA-796-producing NDM-1 ST773 isolate

Sepiolite reinforced alginate-based hydrogels for drug delivery applications

Progressive Symmetric Distal Lower Extremity Weakness, Sensory Loss, and Gait Dysfunction in a Young Adult

Immunologic Response and Clinical Course After Off-label Nonavalent HPV Vaccination in Juvenile-onset Recurrent Respiratory Papillomatosis Patients

Implications of Trauma in Patients With Cervical Ossification of the Posterior Longitudinal Ligament (OPLL)

Difficult Diagnosis: <i>C. Difficile</i> Without Diarrhea

The effect of father-sensitive birth education on antenatal paternal attachment: a single-blind randomized controlled trial

Deep learning aging marker from retinal images unveils sex-specific clinical and genetic signatures

Recent advances in the diagnosis of Turner syndrome karyotype with primary amenorrhoea

Ultra-Processed Foods and Metabolic Dysfunction: Mechanisms, Clinical Implications, and Public Health Perspectives. Position Paper of the Italian Association of Dietetics and Clinical Nutrition (ADI)

Predicting circRNA-Drug Sensitivity Using Integrated Hybrid Graph and Molecular Features

Comparative Analysis of Regulatory Approaches for Artificial Intelligence Enabled Combination Devices in the United States, Europe, and Japan

Correction: Population Approaches to Promoting Relational Health From Early Life

MiR‑365b‑5p and MiR‑3614‑5p are elevated in PBMCs of systemic lupus erythematosus and exhibit potential as complementary diagnostic indicators

Efficacy and clinical outcomes of proximal splenic artery embolization in patients with chemotherapy induced thrombocytopenia

Atrial fibrillation associated with renal tubular injury in acute chest pain: N-acetyl-β-D-glucosaminidase, kidney injury molecule 1, and NT-proBNP as predictive markers

Agentic Document Reasoning for Evidence-Grounded Clinical Report Generation

Longitudinal course of sensory processing difficulties in pediatric obsessive–compulsive disorder: A preliminary naturalistic observational study

Breathe, Eat, Talk: Three Essential Ingredients to Quality‐of‐Life Outcomes in Movement Disorders

Editorial for “Impact of Dapagliflozin on <scp>MRI</scp> ‐Derived Epicardial Adipose Tissue: Secondary Imaging Analysis of a Randomized Trial”

Repetitive Transcranial Magnetic Stimulation in Alzheimer's Disease Cognitive Impairment: A Narrative Review of Clinical Trials

Cystic Medial Degeneration Leading to Popliteal Artery Aneurysm With Distal Embolization

How does steroid avoidance compare with steroid maintenance after kidney transplant in adults?

What are the benefits and risks of thromboelastography (TEG) or thromboelastometry (ROTEM) to monitor and guide hemostatic treatment in adults or children with bleeding?

Effects of Cannabidiol‐Rich Cannabis Oil on Facial Expression Recognition and Theory of Mind in Children With Autism Spectrum Disorder: A Randomized Clinical Trial

NCT07788781: Pain Science Education and Therapeutic Exercise in Adults With Musculoskeletal Pain

Study type: INTERVENTIONAL. Phase: NA.

NCT07788378: Metformin in Elderly Patients With Type 2 Diabetes and Muscle Strength, Muscle Mass, and Physical Function: Positive or Negative Correlation?

Study type: OBSERVATIONAL. Phase: .

NCT07788144: EAA-Guided AN69-oXiris and PMX-HP Therapy in Septic Patients

Study type: INTERVENTIONAL. Phase: NA.

NCT07787884: Development and Pilot Application of a Solution-Focused Intervention for Social Isolation in Elderly Diabetic Foot Patients

Study type: INTERVENTIONAL. Phase: NA.

NCT07787793: Effects of High-Frequency rTMS on Cortical Motor Mapping in Stroke Patients With Severe Upper Limb Impairment (MAP2024SJD)

Study type: INTERVENTIONAL. Phase: NA.

NCT07787195: Low-Level Laser Therapy Versus Isometric Handgrip Exercise On Arteriovenous Fistula Maturation in Hemodialysis Patients

Study type: INTERVENTIONAL. Phase: NA.

NCT07787182: A Study of LY4405094 in Healthy Participants and Participants With Alzheimer's Disease

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07787130: Effect of Immune X on Common Cold Incidence in Healthy Adults

Study type: INTERVENTIONAL. Phase: NA.

NCT07786402: Clinical Outcomes of Prone and Supine Lumbar Traction Matched to Mechanical Bias in Flexion and Extension Subgroups With Lumbosacral Radiculopathy

Study type: INTERVENTIONAL. Phase: NA.

NCT07785193: A Study of Subcutaneous FL115 Monotherapy in Participants With Advanced Solid Tumors

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07782840: QL1706 Plus Neoadjuvant Endocrine Therapy in HR-Positive/HER2-Negative Breast Cancer With a Poor Response to Neoadjuvant Chemotherapy

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07780604: A SINGLE CENTER, 5-PART STUDY TO INVESTIGATE THE SAFETY, TOLERABILITY AND PHARMACOKINETICS OF GAL-101 SALT IN HEALTHY ADULT AND ELDERLY PARTICIPANTS

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07776665: A Clinical Trial of Enlicitide (MK-0616) Formulations in Healthy Participants (MK-0616-044)

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07767344: Impact of Video-Based Patient Education on Physician Trust, Pain, and Anxiety in Laparoscopic Cholecystectomy

Study type: INTERVENTIONAL. Phase: NA.

NCT07576036: International Multi-center Retrospective Study of Patients With Serum Sodium ≤110 mmol/L to Determine the Relationship Between Osmotic Demyelination Syndrome (ODS) and Rapid Correction of Hyponatremia

Study type: OBSERVATIONAL. Phase: .

NCT07528508: A Clinical Trial in Healthy Participants to Study the Effect of a Single Dose of MK-8527 on Levels of Methadone (MK-8527-020)

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07446322: FOLFIRI and Bevacizumab With or Without Pelareorep for Second-Line Treatment of Metastatic RAS-Mutated, Microsatellite-Stable Colorectal Cancer

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07399717: Assessing Role of Probiotics in Children Aged 6-36 Months Treated for Pneumonia

Study type: INTERVENTIONAL. Phase: NA.