Pharmaceutical industry news

Real-world implementation of a pre-consultation patient educational tool for intermediate risk prostate cancer

Pneumonitis after chemoradiotherapy and/or immunotherapy for stage III and IV non-small cell lung cancer is characterized by specific radiologic and quantitative CT features

From surveillance to participation: redefining respiratory virus epidemiology in the era of self-testing

Antibiotic prophylaxis: a sharp tool that could be blunted easily

Chinese Protocol for CNS GCTs

Vitamin D–containing supplementation and depressive symptom severity in adults: A Bayesian systematic review and evidence-structure assessment

Clinical Efficacy and Safety of Icotinib as Adjuvant Therapy for Resected Stage IA Lung Adenocarcinoma: A Real-world Study

Regional (in)Consistency and Comparability of Cannabis Laboratory Testing: A Statistical Exploration of Total Yeast and Mold

Intraoperative study of afferent and efferent connections in the upper lumbar spinal cord – Part 1: Cremasteric reflex

Intraoperative study of afferent and efferent connections in the upper lumbar spinal cord – Part 2: genitoinguinal reflex

Microbe snapshots: Lomentospora prolificans

Determination of Body Perceptions and Preferences for Breast Reconstruction in Mastectomy Patients

The impact of trauma-informed sports-based intervention on emotion regulation, self-esteem, and peer relationships in adolescents with substance use disorder: A randomized controlled trial

International Expert Delphi Consensus on Endoscopic Ultrasound-Guided Portosystemic Pressure Gradient: Best Practices and Future Directions

The Influence of Dietary Emulsifiers on the Gastrointestinal Tract: The Jury Is Still out

Visualization and detection of ciliary beating frequency in human airway organoids based on image correlated methods for drug screening

Based on CT radiomics and clinical features to distinguish pathological subtypes of intrahepatic cholangiocarcinoma: A multicenter study

Microphysiological (“organ-on-a-chip”) models of pulmonary infections for developing novel anti-infectives

NCT07798323: Noninvasive Imaging Biomarkers of Treatable Macrovascular Disease in Age-related Macular Degeneration.

Study type: OBSERVATIONAL. Phase: .

NCT07797556: Use of Apple Vision Pro as Virtual Monitor for Diagnostic and Therapeutic Procedures

Study type: OBSERVATIONAL. Phase: .

NCT07797335: AMBITION 7: A Research Study Investigating How Well Zenagamtide Lowers Blood Sugar and Body Weight Compared to Insulin Glargine in People With Type 2 Diabetes and Increased Risk of Diseases That Affect the Heart and Blood Vessels Treated With 1-3 Other Diabetes Medications

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07796347: Dyadic Life Review Intervention for Older Patients With Advanced Cancer and Alzheimer's Disease and Related Dementias and Their Caregivers

Study type: INTERVENTIONAL. Phase: NA.

NCT07796191: Drug-drug Interactions Studies of VC005 Tablets in Healthy Adult Subjects

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07795502: Dynamic Infection Kinetics for Early Diagnosis, Monitoring, and Prognostication of Sepsis in Adult Oncology Patients: Evaluating Serial Infection Biomarkers, Blood Culture Kinetics, Treatment Response, Disease Severity, and Clinical Outcomes

Study type: OBSERVATIONAL. Phase: .

NCT07776327: Analyzing Positional Release Therapy and Dry Needling

Study type: INTERVENTIONAL. Phase: NA.

NCT07726069: Haloperidol For Outpatient Symptom Management in Patients Diagnosed With Cannabinoid Hyperemesis Syndrome in the Emergrency Department

Study type: INTERVENTIONAL. Phase: EARLY_PHASE1.

NCT07701772: LASER VERSUS CRYSTALLIZED PHENOL IN PILONIDAL SINUS DISEASE

Study type: INTERVENTIONAL. Phase: NA.

NCT07693868: A Study to See How Safe a New Medicine (NNC6022-0004) is in Healthy People and People Living With Obesity

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07690839: Pre-Clinic Visit Online Education for Thyroid Cancer

Study type: INTERVENTIONAL. Phase: NA.

NCT07392372: A Clinical Trial Investigating the Safety and Biological Activity of the Antibody BNT351 in Adults Living Without and With HIV

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07294664: PDL1/TGFβ In Combination With SHR2554 or Apatinib And Chemotherapy For First - Line Treatment Of Gastric Cancer

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07222917: A Phase IIb Study to Evaluate the Effect of Dapagliflozin in Combination With Baxdrostat Compared With Baxdrostat on Albuminuria in Participants With Chronic Kidney Disease and High Blood Pressure.

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07160530: Healthy Children, Healthy Communities: Effectiveness of a Multilevel Rural Community Engagement Model for Improving Children's Dietary Intake in Family Child Care Homes

Study type: INTERVENTIONAL. Phase: NA.

NCT07105735: RN1201 Injection for Autoimmune Diseases Refractory to Standard Therapies

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07027826: The Esophageal String Test as a Diagnostic Screening Tool for Eosinophilic Esophagitis Among Africans With Dysphagia in Mali and the United States

Study type: INTERVENTIONAL. Phase: NA.

NCT06938178: High-Density EEG-MEG-wearable EEG: Comparison of Quantitative Electroencephalographic Indicators as Neurophysiological Markers of Effectiveness of Mindfulness Therapy in Addition to Standard Treatment in Patients With High-frequency Episodic Migraine

Study type: OBSERVATIONAL. Phase: .

NCT06890338: A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT06743529: Immediate Versus Substantiated Antibiotic Therapy in Suspected Non-Severe Ventilator-Associated Pneumonia

Study type: INTERVENTIONAL. Phase: NA.

NCT06481319: Implementing a Pilot Patient Navigator Program to Improve Access to Infertility Care for Underserved Patients

Study type: INTERVENTIONAL. Phase: NA.

NCT06340568: A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT06325683: Anti-Lag-3 (Relatlimab) and Anti-PD-1 Blockade (Nivolumab) Versus Standard of Care (Lomustine) for the Treatment of Patients With Recurrent Glioblastoma

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT06222203: Surveillance for Malignant Transformation of Neurofibromatosis Type 1 (NF1) Related Peripheral Nerve Sheath Tumors (PNST)

Study type: OBSERVATIONAL. Phase: .

NCT05656378: A Repository to Study Host-Microbiome Interactions in Health and Disease

Study type: OBSERVATIONAL. Phase: .

NCT05653037: A Single Ascending Doses Phase I Study to Evaluate the Safety and Pharmacokinetics of RBD4059 in Healthy Subjects

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT05276973: Testing the Addition of Ipatasertib to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) for Stage III or IV Epithelial Ovarian Cancer

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT05152147: A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT05026723: Food as Medicine for HIV and Diabetes

Study type: INTERVENTIONAL. Phase: NA.

NCT04977986: Clinical Study of Cannabidiol in Children, Adolescents, and Young Adults With Fragile X Syndrome

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT04933539: Subcutaneous Daratumumab, Once Weekly Carfilzomib, and Dexamethasone (DKd) in Patients With High-Risk Smoldering Multiple Myeloma

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT04609046: Testing the Addition of Lenalidomide and Nivolumab to the Usual Treatment for Primary CNS Lymphoma

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT04484272: A Stress and Pain Self-management m-Health App for Adult Outpatients With Sickle Cell Disease

Study type: INTERVENTIONAL. Phase: NA.

NCT04269239: Effectiveness of Healthy Habits for Hospitalized Older Adults to Optimize Rehabilitation

Study type: INTERVENTIONAL. Phase: NA.

NCT04266093: Gene Therapy Follow up Protocol for Subjects Previously Enrolled in NCI Center for Immuno-Oncology Studies

Study type: OBSERVATIONAL. Phase: .

NCT04124341: PCS in Severe Treatment Resistant Depression

Study type: INTERVENTIONAL. Phase: NA.

NCT03910452: Haploidentical Transplant for People With Chronic Granulomatous Disease (CGD) Using Alemtuzumab, Busulfan and TBI With Post-Transplant Cyclophosphamide

Study type: INTERVENTIONAL. Phase: EARLY_PHASE1.

NCT03604991: Nivolumab and Ipilimumab in Treating Patients With Esophageal and Gastroesophageal Junction Adenocarcinoma Undergoing Surgery

Study type: INTERVENTIONAL. Phase: PHASE2, PHASE3.

NCT03581318: Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging

Study type: OBSERVATIONAL. Phase: .

NCT03538600: Sample Collection From Healthy Volunteers for Assay Optimization

Study type: OBSERVATIONAL. Phase: .

NCT03510442: Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions

Study type: OBSERVATIONAL. Phase: .

NCT03401385: First-in-human Study of DS-1062a for Advanced Solid Tumors (TROPION-PanTumor01)

Study type: INTERVENTIONAL. Phase: PHASE1.