Pharmaceutical industry news

Varying Cancer Drug Doses to Balance Tumor Control and Resistance Evolution

Supplementary Information from Evolutionary Antifragile Therapy Is a Treatment Strategy to Suppress Drug Resistance by Exploiting Dose–Response Convexity

Figure 2 from KRAS Inhibitor–Induced Cancer Cell Death Enhances Sensitivity to Immune-Mediated Bystander Killing of Drug-Resistant Subclones

Figure 5 from KRAS Inhibitor–Induced Cancer Cell Death Enhances Sensitivity to Immune-Mediated Bystander Killing of Drug-Resistant Subclones

Figure S11 from KRAS Inhibitor–Induced Cancer Cell Death Enhances Sensitivity to Immune-Mediated Bystander Killing of Drug-Resistant Subclones

Figure S4 from KRAS Inhibitor–Induced Cancer Cell Death Enhances Sensitivity to Immune-Mediated Bystander Killing of Drug-Resistant Subclones

Figure S5 from KRAS Inhibitor–Induced Cancer Cell Death Enhances Sensitivity to Immune-Mediated Bystander Killing of Drug-Resistant Subclones

Table S3 from KRAS Inhibitor–Induced Cancer Cell Death Enhances Sensitivity to Immune-Mediated Bystander Killing of Drug-Resistant Subclones

Secondary use and scholarly impact of a portfolio of clinical trials with shared individual participant level data: cross sectional study

Professional Identity Formation in the Transition From Undergraduate to Postgraduate Medical Education: A Scoping Review

Pharmacological Targets for Periodontitis: A Systematic Review of Drug‐Target Mendelian Randomisation Studies

Response to “Efficacy and Safety of Tegoprazan‐Amoxicillin Dual Therapy for <scp> <i>Helicobacter pylori</i> </scp> Eradication: A Systematic Review and Meta‐Analysis With Trial Sequential Analysis of Randomized Controlled Trials”

Treatment escalation patterns, infection risk and clinical outcomes in refractory <scp>CCLE</scp> in <scp>SLE</scp>

Perceptions of doctors disclosing AI use in their online biographies: evidence from an experiment

A phase-based analytic hierarchy process–decision–making trial and evaluation laboratory approach for prioritizing building information modelling–enabled digital transformation criteria in geotechnical projects: the case of Türkiye

Phosphodiesterase-5 Inhibitor Use and Clinical Outcomes in Left Ventricular Assist Device Recipients: A Real-World Analysis of 31,465 Patients

Iron deficiency during pregnancy and lactation

Effects of Upper Extremity Strength Exercises in Subacromial Impingement Syndrome: A Systematic Review

Development of adjuvanted HIV vaccines tailored for early life: immunologic rationale, clinical experience, and future directions

Complete revascularization according to age in patients with ST-segment elevation myocardial infarction and multivessel disease: 10-year outcome from the DANAMI-3–PRIMULTI trial

Modeling uncertainty in performance validity testing with Bayesian logistic regression

Lived experience in layers – personal, professional and partnership: an autoethnographic exploration of the evaluation of a drug education programme

Discovery and preclinical validation of a translationally optimized mitochondrial complex I modulator for Alzheimer’s disease

An umbrella review of ethical challenges in clinical trials conducted in low and middle income countries

AI-driven drug discovery and personalized medicine: integrating quantum computing and next-generation technologies

Prognostic Markers in CKD Patients Stratified by Co-morbid Conditions and on Dialysis Therapy

Socioeconomic Inequalities in Dietary Diversity and Nutritional Status Among Early School-age Children in Bankura District of West Bengal, India

Optic nerve sheath diameter by ocular ultrasonography rapidly detects high intracranial pressure in acute meningitis

Screening of sarcopenia in long-term care facilities using wireless surface electromyography and deep transfer learning: a proof-of-concept study

ISoP MENA Chapter: Strategic Development and Future Directions Following a Decade of Strengthening Pharmacovigilance in the Middle East and North Africa

Delivery of liothyronine by microneedle patch for the treatment of hypothyroidism

The protamine-to-heparin ratio: concept and clinical application

Clinical outcomes of stereotactic body radiotherapy in oligometastatic disease: a national real-world cohort study

Epidemic Thunderstorm Asthma in China: A Systematic Review of an Artemisia-Associated Phenotype

Radiomics and artificial intelligence in pituitary adenomas (PitNETs): from imaging biomarkers to clinical translation

Effectiveness and safety of Janus Kinase inhibitors in patients with rheumatoid arthritis, results from a multicenter observational “real-life” GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) study

Evaluation of the physicochemical properties and adhesive interface quality of BioRoot Flow and BioRoot RCS endodontic sealers: An in vitro study

Drug‐Derived Tetrahydropyrazines for Late‐Stage <i>α</i> ‐ and <i>β</i> ‐Functionalization of Piperazine‐Based Pharmaceuticals

NCT07799909: Behavioral Activation for Cancer-Related Fatigue After Breast Cancer Surgery

Study type: INTERVENTIONAL. Phase: NA.

NCT07799467: Implementing a Digital Alcohol Intervention to Raise Women's Awareness of Alcohol-related Breast Cancer Risk During Routine Screening Visits

Study type: INTERVENTIONAL. Phase: NA.

NCT07799012: Sexual Quality of Life in Female Patients With Lipodystrophy Syndromes or Turner's Syndrome: a Case-control Study

Study type: OBSERVATIONAL. Phase: .

NCT07798999: Anodic Stimulation in Parkinson's Disease

Study type: INTERVENTIONAL. Phase: NA.

NCT07798986: Acupuncture for Generalized Anxiety Disorder

Study type: INTERVENTIONAL. Phase: NA.

NCT07798310: Protocol for Rapid Onset of Mobilization in Patients With Traumatic Spinal Cord Injury III (PROMPT-SCI III) Trial

Study type: INTERVENTIONAL. Phase: NA.

NCT07795528: Postoperative Circulating Tumor DNA Monitoring in Stage I-III Driver-Mutant Colon Adenocarcinoma

Study type: OBSERVATIONAL. Phase: .

NCT07738224: Using the Babble Boot Camp© Speech Therapy Approach With Babies Born Prematurely

Study type: INTERVENTIONAL. Phase: NA.

NCT07681505: Analysis of the Role of the Microbiota in Diverticular Disease

Study type: OBSERVATIONAL. Phase: .

NCT07679958: Immersive Virtual Reality Applied to Therapeutic Physical Exercise in Cellular Therapy

Study type: INTERVENTIONAL. Phase: NA.

NCT07673887: A Study of ASP2138 Together With Chemotherapy and Pembrolizumab in Adults With Gastric Cancer

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07622186: A Study of SKB571 Combination Therapy in Participants With Non-Small Cell Lung Cancer (NSCLC)

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07613099: Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74) PET/CT Imaging

Study type: INTERVENTIONAL. Phase: PHASE3.

NCT07607730: Regulating Together for Prader-Willi Syndrome: A Group Behavioral Therapy for Emotion Dysregulation

Study type: INTERVENTIONAL. Phase: NA.

NCT07570862: A Phase 2, Open-Label, Single-Arm Trial of FT819 in Participants With Lupus Nephritis

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07565974: THC Versus THC/CBD Versus Placebo to Improve Sleep Quality for Patients With Solid Organ Cancer and Insomnia

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07563998: Prehospital Point-of-Care Hs-Troponin I for Rule-Out of Acute Myocardial Infarction in Patients Without ST-Segment Elevation

Study type: OBSERVATIONAL. Phase: .

NCT07501039: A Phase 1 Study of BLKR201 in Healthy Adult Participants

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07369024: Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young Adults

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07363408: Ivonescimab and ADG126, Alone, and in Combination With Leucovorin and Fluorouracil or FOLFIRI Regimen for the Treatment of Microsatellite Stable Advanced/Metastatic Colorectal Cancer

Study type: INTERVENTIONAL. Phase: PHASE1.

NCT07292298: Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates

Study type: INTERVENTIONAL. Phase: PHASE2.

NCT07235514: Anesthesia Management in Endovascular Therapy for Ischemic Stroke - 2

Study type: INTERVENTIONAL. Phase: NA.